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Table 2 Methylated motifs detected in HP14039

From: The complete genome and methylome of Helicobacter pylori hpNEAfrica strain HP14039

Recognition sitea Modification type No. detected No. in genome Detected (%) Restriction component(s) Methylation component(s) Refs
Locus tag Ortholog % identity Locus tag Ortholog % identity
5′-ACNGT m4c 976 1112 87.8 HP14039_01407-01406 K747_11000 94.1, 93.9 HP14039_01408 K747_10995 95.5 [8]
5′-ATTAAT m6a 949 952 99.7 HP14039_01410 jhp0431 94.1 HP14039_01411 jhp0430 94.9 [26, 29]
5′-CATG m6a 14,872 14,874 100 HP14039_00716 hp1209 93.3 HP14039_00717 hp1208 93.8 [29]
5′-CCATC m6a 2190 2199 99.6 HP14039_00375-00376 K747_12645 95.7, 92.7 HP14039_00372-00373 K747_03690 96.2, 97.7 [8]
5′-CCGG m4c 3535 3542 99.8 HP14039_01604 hp0262 96.1 HP14039_01603 hp0263 94.2 [29]
5′-CTNAG m4c 6164 6172 99.9 HP14039_01555 HpyHI 96 HP14039_01554 M.HpyHI 94.9 [30]
5′-GAGG m6a 4672 4718 99 HP14039_00203b HP14039_00204 hp0050 95.2 [26, 29]
5′-GATC m6a 10,541 10,548 99.9 HP14039_00158 hp0091 93.7 HP14039_00157 hp0092 92.8 [29]
5′-GTAC m6a 300 304 98.7 HP14039_01382-01381 jhp0455 93.4, 93.7 HP14039_01383 jhp0454 95.8 [26, 31]
5′-GTNNAC m6a 820 826 99.3 HP14039_00987 hp0909 91.7 HP14039_00986 hp0910 96.1 [29]
5′-TCGA m6a 610 612 99.7 HP14039_01606-01607 hp0260 96.1, 97.6 [32]
5′-TCNNGA m6a 3795 3808 99.7 HP14039_00847-00846 jhp1013c 96.8, 97.5 HP14039_00848 jhp1012 96.1 [26]
5′-TGCA m6a 11,060 11,072 99.9 HP14039_00305 HpyCH4 V 96.6 HP14039_00306 M.HpyCH4 V 93.4 [12, 30]
5′-CTANNNNNNNTAYG m6a 191 192 99.5 HP14039_00325d K747_03505 93 [8]
5′-WCANHNNNNTG m6a 1732 4440 39 HP14039_01429e K747_10905 92 [8]
  1. aThe methylated base within the motif is underlined while the modified base in the complementary strand is highlighted in red
  2. bThe 1–563 bp and 550–918 bp regions of HP14039_00203 demonstrated significant nucleotide sequence homology to the N-terminus of hp0052 and the C-terminus of hp0051, respectively
  3. cPutative type II restriction enzyme probably recognising TCNNGA
  4. dPredicted type I DNA methylase probably recognising CTANNNNNNNTAYG based on high sequence similarity with K747_03505 that recognises a closely related sequence motif, which is GANNNNNNNTAYG
  5. ePredicted type I DNA methylase probably recognising WCANHNNNNTG. This gene is highly similar to K747_10905, which encodes a type I DNA methylase that recognises CCANNNNNNTC sequence motif