Table 3 Inactivation mutations in rdxA and frxA genes in sequenced metronidazole-resistant H. pylori strains
Strain | MIC (µg/ml) | rdxA | frxA |
|---|---|---|---|
Mutation type (position) | Mutation type (position) | ||
KH1 | 64 | Nonsense (65) | – |
KH2 | 64 | – | – |
KH3 | 64 | Nonsense (50) | Nonsense (199) |
KH4 | 16 | Nonsense (50) | – |
KH6 | 64 | – | Frameshift (70) |
KH7 | 64 | – | Nonsense (68) |
KH8 | 64 | Frameshift (136) | Frameshift (18) |
KH9 | 32 | – | Deletion of 58 bp C-terminal region |
KH11 | 64 | – | – |
KH12 | 64 | Frameshift (65) | Deletion of 303 bp N-terminal region |
KH13 | 64 | – | Frameshift (18) |
KH14 | 64 | – | Nonsense (141) |
KH15 | 64 | – | – |
KH16 | 64 | – | – |
KH17 | 64 | Nonsense (50) | – |
KH18 | 64 | Fragmented | – |
KH19 | 64 | – | Frameshift (44) |
KH20 | 64 | – | – |
KH21 | 64 | Nonsense (50) | Frameshift (70) |
KH22 | 32 | Nonsense (50) | – |
KH23 | 32 | – | Frameshift (154) |
KH25 | 64 | – | Frameshift (18) |
KH26 | 64 | – | Nonsense (68) |
KH27 | 64 | – | – |
KH28 | 64 | Frameshift (98) | Frameshift (18) |
KH29 | 64 | – | – |
KH30 | 64 | Frameshift (185) | Nonsense (86) |
KH32 | 16 | – | – |
KH33 | 64 | – | Frameshift (18) |
KH36 | 32 | Frameshift (161) | – |
KH37 | 64 | Nonsense (65) | – |
KH38 | 64 | Nonsense (50) | Frameshift (18) |
KH41 | 64 | – | 268 bp insertion |
KH43 | 64 | Frameshift (72) | Nonsense (176) |
KH44 | 64 | – | – |
KH45 | 64 | – | Frameshift (106) |