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Table 3 Discrete filtration

From: Whole exome sequencing of patients who resolved Crohn’s disease and complex regional pain syndrome following treatment for paratuberculosis

Inheritance model

1

2

3

4

5

6

Sequence ontology

24,623

26,950

24,623

26,950

29,197

29,612

European allele frequency ≤ 0.05 or missing

11,024

12,864

3144

13,899

15,089

15,592

Variants shared among affected members

903

655

974

1432

1869

1500

Variants absent from normal or not called

110

96

2

16

73

2

Sequence read depth ≥ 10 for all patients

95

89

1

15

68

1

Polyphen = possibly or probably damaging or

57

56

1

14

41

1

Inheritance model

7

8

9

10

11

12

Sequence ontology

24,623

26,950

24,623

26,949

29,197

29,612

European Allele ≤ frequency 0.05 or missing

11,024

12,864

3144

13,898

15,089

15,592

Variants shared among affected members

2228

1213

1012

1636

3239

1816

Variants absent from normal or not called

577

292

6

34

353

14

Sequence read depth ≥ 10 for all patients

142

111

2

17

73

3

Polyphen = possibly or probably damaging or

91

74

1

16

45

2

  1. We screened for relevant variants using twelve different genetic models as described in Table 2. Rows provide the number of variants following application of each filtering criterion