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Table 1 Mutations observed in outcome strains

From: Genome-wide mutation analysis of Helicobacter pylori after inoculation to Mongolian gerbils

Strains   Position Mutation Depth Ratio Gene Amino acid change
TN2-1M (1) 31255 C → A 1025 99.7 Outer membrane protein (hefG) A61S
(2) 517741 G → A 569 99.7 Glutathione-regulated potassium-efflux system protein (kefB) N232S
(3) 517792 T → C 676 99.7 A249V
(4) 1241193 Insertion 625 96.6 Outer membrane protein (hofH) Frameshift without stop
(5) 1297623 A → G 776 99.5 Urease accessory protein (ureI) H131R
(6) 1496148 A → C 529 95.1 Glutamate permease (gltS) W131G
TN2-3M (2) 112286 G → A 866 93.6 Dinucleoside polyphosphate hydrolase R139C
(5) 188008 C → G 766 100.0 Type II restriction enzyme R protein (hsdR) R173T
(6) 194568 G → T 774 99.6 Uncharacterized protein G201W
(7) 926807 Insertion 773 97.0 cag pathogenicity island protein (cag8) Stop at 136th codon
(8) 1007324 A → G 867 99.1 Outer membrane protein (hopB) T123A
(9) 1202841 G → A 780 99.9 F0F1 ATP synthase subunit alpha P470L
TN2-6M (3) 935451 C → T 691 99.9 P-type DNA transfer ATPase (virB11) H314Y
(4) 989679 Deletion 629 95.0 Outer membrane protein (babA) Stop at 93th codon
(5) 1174908 C → A 570 94.4 Lipopolysaccharide biosynthesis proteins G154W
(6) 1251850 Insertion 605 91.8 Outer membrane protein Stop at 305th codon
TN2-3M (1) 87451 Deletion 853 95.2 Oligopeptide ABC transporter periplasmic oligopeptide-binding protein (oppA) Stop at 464th codon
TN2-6M (1) 791 96.3
TN2-3M (3) 175008 G → T 591 97.8 Methyl-accepting chemotaxis protein (tlpB) G26W
(4) 175755 G → T 795 99.9 G275W
TN2-6M (2) 175691 Deletion 810 99.9 Stop at 256th codon
  1. Position indicates the location of the mutation in the TN2 genome. Depth and ratio represent number of reads that covered the locus and percentage of the mutated reads, respectively. Numbers in the parentheses correspond with those in Fig. 1