From: Genome-wide mutation analysis of Helicobacter pylori after inoculation to Mongolian gerbils
Strains | Â | Position | Mutation | Depth | Ratio | Gene | Amino acid change |
---|---|---|---|---|---|---|---|
TN2-1M | (1) | 31255 | C → A | 1025 | 99.7 | Outer membrane protein (hefG) | A61S |
(2) | 517741 | G → A | 569 | 99.7 | Glutathione-regulated potassium-efflux system protein (kefB) | N232S | |
(3) | 517792 | T → C | 676 | 99.7 | A249V | ||
(4) | 1241193 | Insertion | 625 | 96.6 | Outer membrane protein (hofH) | Frameshift without stop | |
(5) | 1297623 | A → G | 776 | 99.5 | Urease accessory protein (ureI) | H131R | |
(6) | 1496148 | A → C | 529 | 95.1 | Glutamate permease (gltS) | W131G | |
TN2-3M | (2) | 112286 | G → A | 866 | 93.6 | Dinucleoside polyphosphate hydrolase | R139C |
(5) | 188008 | C → G | 766 | 100.0 | Type II restriction enzyme R protein (hsdR) | R173T | |
(6) | 194568 | G → T | 774 | 99.6 | Uncharacterized protein | G201W | |
(7) | 926807 | Insertion | 773 | 97.0 | cag pathogenicity island protein (cag8) | Stop at 136th codon | |
(8) | 1007324 | A → G | 867 | 99.1 | Outer membrane protein (hopB) | T123A | |
(9) | 1202841 | G → A | 780 | 99.9 | F0F1 ATP synthase subunit alpha | P470L | |
TN2-6M | (3) | 935451 | C → T | 691 | 99.9 | P-type DNA transfer ATPase (virB11) | H314Y |
(4) | 989679 | Deletion | 629 | 95.0 | Outer membrane protein (babA) | Stop at 93th codon | |
(5) | 1174908 | C → A | 570 | 94.4 | Lipopolysaccharide biosynthesis proteins | G154W | |
(6) | 1251850 | Insertion | 605 | 91.8 | Outer membrane protein | Stop at 305th codon | |
TN2-3M | (1) | 87451 | Deletion | 853 | 95.2 | Oligopeptide ABC transporter periplasmic oligopeptide-binding protein (oppA) | Stop at 464th codon |
TN2-6M | (1) | 791 | 96.3 | ||||
TN2-3M | (3) | 175008 | G → T | 591 | 97.8 | Methyl-accepting chemotaxis protein (tlpB) | G26W |
(4) | 175755 | G → T | 795 | 99.9 | G275W | ||
TN2-6M | (2) | 175691 | Deletion | 810 | 99.9 | Stop at 256th codon |