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Table 5 Clinical performance of the Vibrant GPP array with clinical samples

From: Evaluation of the Vibrant DNA microarray for the high-throughput multiplex detection of enteric pathogens in clinical samples

Vibrant GPP panel No. of positive samples No. of negative samples Sensitivity % (95% CI) Specificity % (95% CI) PPV %
(95% CI)
NPV  %
(95% CI)
E. coli O157:H7 25 1028 96.2
(80.4–99.9)
99.9
(99.5–100)
96.2
(80.4–99.9)
99.9
(99.5–100)
Enteroaggregative E. coli (EAEC) 8 1046 100
(63.1–100)
99.9
(99.5–100)
88.9
(63.1–100)
100
(99.5–100)
Enteropathogenic E. coli (EPEC) 17 1038 100
(80.5–100)
100
(99.6–100)
100
(80.5–100)
100
(99.6–100)
Enterotoxigenic E. coli (ETEC) lt/st 6 1047 100
(54.1–100)
99.8
(99.3–100)
75.0
(54.1–100)
100
(99.3–100)
Shiga-like toxin producing E. coli (STEC) stx1/stx2 12 1042 92.3
(64.0–99.8)
100
(99.6–100)
100
(64.0–99.8)
99.9
(99.6–100)
Plesiomonas shigelloides 4 1050 80
(28.4–99.5)
100
(99.6–100)
100
(28.4–99.5)
99
(99.6–100)
Helicobacter pylori 4 1051 100
(39.8–100)
100
(99.6–100)
100
(39.8–100)
100
(99.6–100)
Listeria spp. 7 1048 100
(59.0–100)
100
(99.6–100)
100
(59.0–100)
100
(99.6–100)
Vibrio cholerae 5 1048 100
(47.8–100)
99.8
(99.3–100)
71.4
(47.8–100)
100
(99.3–100)
C. difficile Toxin A/B 10 1043 91.7
(61.5–99.8)
99.9
(99.5–100)
91.7
(61.5–99.8)
99.9
(99.5–100)
Salmonella spp. 13 1042 100
(75.3–100)
100
(99.6–100)
100
(75.3–100)
100
(99.6–100)
Shigella/Enteroinvasive E. coli (EIEC) 5 1049 83.3
(35.9–99.6)
100
(99.6–100)
100
(35.9–99.6)
99.9
(99.6–100)
Yersinia enterocolitica 12 1042 92.3
(64.0–99.8)
100
(99.6–100)
100
(64.0–99.8)
99.9
(99.6–100)
Campylobacter jejuni 7 1047 87.5
(47.4–99.7)
100
(99.6–100)
100
(47.4–99.7)
99.9
(99.6–100)
Campylobacter upsaliensis 3 1051 100
(30.0–100)
99.9
(99.5–100)
75.0
(30.0–100)
100
(99.5–100)
Giardia lamblia 8 1047 100
(63.1–100)
100
(99.6–100)
100
(63.1–100)
100
(99.6–100)
Entamoeba histolytica 6 1049 100
(54.1–100)
100
(99.6–100)
100
(54.1–100)
100
(99.6–100)
Cyclospora cayetanensis 3 1050 100
(30.0–100)
99.8
(99.3–100)
60.0
(30.0–100)
100
(99.3–100)
Norovirus GI/GII 12 1042 92.3
(64.0–99.8)
100
(99.6–100)
100
(64.0–99.8)
99.9
(99.6–100)
Rotavirus A 4 1051 100
(39.8–100)
100
(99.6–100)
100
(39.8–100)
100
(99.6–100)
Adenovirus F 40/41 7 1048 100
(59.0–100)
100
(99.6–100)
100
(59.0–100)
100
(99.6–100)
Astrovirus 4 1052 100
(39.8–100)
100
(99.6–100)
100
(39.8–100)
100
(99.6–100)
Sapovirus (I, II, IV, V) 3 1050 100
(47.8–100)
100
(99.6–100)
100
(47.8–100)
100%
(99.6–100)
Candida spp. 26 1027 96.3
(81.0–99.9)
99.8
(99.3–100)
92.9
(81.0–99.9)
99.9
(99.3–100)