Table 5 Clinical performance of the Vibrant GPP array with clinical samples
Vibrant GPP panel | No. of positive samples | No. of negative samples | Sensitivity % (95% CI) | Specificity % (95% CI) | PPV % (95% CI) | NPV % (95% CI) |
|---|---|---|---|---|---|---|
E. coli O157:H7 | 25 | 1028 | 96.2 (80.4–99.9) | 99.9 (99.5–100) | 96.2 (80.4–99.9) | 99.9 (99.5–100) |
Enteroaggregative E. coli (EAEC) | 8 | 1046 | 100 (63.1–100) | 99.9 (99.5–100) | 88.9 (63.1–100) | 100 (99.5–100) |
Enteropathogenic E. coli (EPEC) | 17 | 1038 | 100 (80.5–100) | 100 (99.6–100) | 100 (80.5–100) | 100 (99.6–100) |
Enterotoxigenic E. coli (ETEC) lt/st | 6 | 1047 | 100 (54.1–100) | 99.8 (99.3–100) | 75.0 (54.1–100) | 100 (99.3–100) |
Shiga-like toxin producing E. coli (STEC) stx1/stx2 | 12 | 1042 | 92.3 (64.0–99.8) | 100 (99.6–100) | 100 (64.0–99.8) | 99.9 (99.6–100) |
Plesiomonas shigelloides | 4 | 1050 | 80 (28.4–99.5) | 100 (99.6–100) | 100 (28.4–99.5) | 99 (99.6–100) |
Helicobacter pylori | 4 | 1051 | 100 (39.8–100) | 100 (99.6–100) | 100 (39.8–100) | 100 (99.6–100) |
Listeria spp. | 7 | 1048 | 100 (59.0–100) | 100 (99.6–100) | 100 (59.0–100) | 100 (99.6–100) |
Vibrio cholerae | 5 | 1048 | 100 (47.8–100) | 99.8 (99.3–100) | 71.4 (47.8–100) | 100 (99.3–100) |
C. difficile Toxin A/B | 10 | 1043 | 91.7 (61.5–99.8) | 99.9 (99.5–100) | 91.7 (61.5–99.8) | 99.9 (99.5–100) |
Salmonella spp. | 13 | 1042 | 100 (75.3–100) | 100 (99.6–100) | 100 (75.3–100) | 100 (99.6–100) |
Shigella/Enteroinvasive E. coli (EIEC) | 5 | 1049 | 83.3 (35.9–99.6) | 100 (99.6–100) | 100 (35.9–99.6) | 99.9 (99.6–100) |
Yersinia enterocolitica | 12 | 1042 | 92.3 (64.0–99.8) | 100 (99.6–100) | 100 (64.0–99.8) | 99.9 (99.6–100) |
Campylobacter jejuni | 7 | 1047 | 87.5 (47.4–99.7) | 100 (99.6–100) | 100 (47.4–99.7) | 99.9 (99.6–100) |
Campylobacter upsaliensis | 3 | 1051 | 100 (30.0–100) | 99.9 (99.5–100) | 75.0 (30.0–100) | 100 (99.5–100) |
Giardia lamblia | 8 | 1047 | 100 (63.1–100) | 100 (99.6–100) | 100 (63.1–100) | 100 (99.6–100) |
Entamoeba histolytica | 6 | 1049 | 100 (54.1–100) | 100 (99.6–100) | 100 (54.1–100) | 100 (99.6–100) |
Cyclospora cayetanensis | 3 | 1050 | 100 (30.0–100) | 99.8 (99.3–100) | 60.0 (30.0–100) | 100 (99.3–100) |
Norovirus GI/GII | 12 | 1042 | 92.3 (64.0–99.8) | 100 (99.6–100) | 100 (64.0–99.8) | 99.9 (99.6–100) |
Rotavirus A | 4 | 1051 | 100 (39.8–100) | 100 (99.6–100) | 100 (39.8–100) | 100 (99.6–100) |
Adenovirus F 40/41 | 7 | 1048 | 100 (59.0–100) | 100 (99.6–100) | 100 (59.0–100) | 100 (99.6–100) |
Astrovirus | 4 | 1052 | 100 (39.8–100) | 100 (99.6–100) | 100 (39.8–100) | 100 (99.6–100) |
Sapovirus (I, II, IV, V) | 3 | 1050 | 100 (47.8–100) | 100 (99.6–100) | 100 (47.8–100) | 100% (99.6–100) |
Candida spp. | 26 | 1027 | 96.3 (81.0–99.9) | 99.8 (99.3–100) | 92.9 (81.0–99.9) | 99.9 (99.3–100) |