From: Is there any association between gut microbiota and type 1 diabetes? A systematic review
Authors | Year | Country | Type of study | Study population (control and case) | Age (mean) | Microbiota analysis technique |
---|---|---|---|---|---|---|
Rozanova et al. [41] | 2002 | Russia | Cohort | 38 T1D | 3 years | Not mentioned |
Brown et al. [23] | 2011 | Finland | Case–control | 8 T1D | Children | DNA sequencing |
Giongo et al. [31] | 2011 | USA | Case–control | Control: 4, case: 4 | 5 months | 16s rRNA sequencing |
Murri et al. [26] | 2013 | Spain | Case–control | Control: 16, case: 16 | 7 years | Real time quantitative PCR |
Richardson et al. [37] | 2014 | Finland | Cohort | Control: 47, case: 29 | 2 years | 16s rRNA sequencing |
de Goffau et al. [24] | 2014 | Netherlands | Case–control | Control: 27, case: 28 | 3 years | Microarray analysis |
Endesfelder et al. [38] | 2014 | Germany | Cohort | Control: 22, case: 22 | 19.5 months | 16s rRNA sequencing |
Mejia et al. [30] | 2014 | Mexico | Case–control | Control: 8, case: 21 | 12.5 years | 16s rRNA pyrosequencing |
Soyucen et al. [28] | 2014 | Turkey | Case–control | Control: 35, case: 35 | 10 years | Quantitative cultures on selective and non-selective media |
Kostic et al. [39] | 2015 | Finland | Cohort | Control: 22, case: 11b | Infants | 16s rRNA sequencing |
Alkanani et al. [5] | 2015 | USA | Cross-sectional | Control: 23, casea: 88 | 11 years | 16s rRNA sequencing |
Cui et al. [18] | 2016 | China | Case–control | Control: 15, case: 15 | 11 years | 16s rRNA sequencing |
Maffeis et al. [25] | 2016 | Italy | Case–control | Control: 10, case: 10 | 11 years | Semi-quantitative PCR |
Stewart et al. [29] | 2017 | UK | Case–control | Control: 10, case: 10 | 27 years | 16s rRNA sequencing |
Pinto et al. [40] | 2017 | Portugal | Cohort | Control: 3, case: 3 | 9 years | Real time quantitative PCR |
Pellegrini et al. [27] | 2017 | Italy | Case–control | Control: 35c, case: 19 | 36 years | Real time quantitative PCR |
Traversi et al. [21] | 2017 | Italy | Case–control | Control: 13, case: 13 | 8 years | Real time quantitative PCR |
Gao et al. [42] | 2018 | France | Cohort | 33 genetically predisposed to T1D | 1.5 years | 16s rRNA sequencing |
Vatanen et al. [44] | 2018 | USA | Nested case–control | Control: 415, case: 368d | 3 month | 16s rRNA sequencing |
Stewart et al. [45] | 2018 | USA | Nested case–control | 903 children | 24.5 month | 16s rRNA sequencing |
Huang et al. [32] | 2018 | China | Case–control | Control: 10, case: 12 | 23.5 | 16s rRNA sequencing |
Gavin et al. [43] | 2018 | Australia | Cross-sectional | Control: 22, case: 69e | 10.8 | Proteomics and 16S rRNA sequencing |
Leiva-Gea et al. [33] | 2018 | Spain | Case–control | Control: 13, case: 15 T1D | 12.6 | 16S rRNA pyrosequencing |
Higuchi et al. [34] | 2018 | Brazil | Case–control | Control: 28, case: 20 | 23.1 | 16s rRNA sequencing |
Salamon et al. [35] | 2018 | Poland | Case–control | Control: 23, case: 22 | 42.5 | 16s rRNA sequencing |
Cinek et al. [36] | 2018 | Czech federation | Case–control | Control: 103, case: 73f | 11.8 | 16s rRNA sequencing |