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Fig. 5 | Gut Pathogens

Fig. 5

From: CagA orchestrates eEF1A1 and PKCδ to induce interleukin-6 expression in Helicobacter pylori-infected gastric epithelial cells

Fig. 5

Postulated mechanism by which CagA promotes the expression of IL-6 in gastric cancer. CagA dysregulated the gp130/NF-κB/STAT3 pathway by recruiting PKCδ through eEF1A1 in the cytoplasm and increasing the accumulation of p-STAT3 S727 in the nucleus. CagA, cytotoxin-associated gene A; eEF1A1, eukaryotic translation elongation factor 1-alpha 1; PKC, protein kinase C; IL-6, interleukin-6; STAT3, signal transducer and activator of transcription 3; gp130, glycoprotein 130; NF-κB, nuclear factor kappa-B

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Gut Pathogens

ISSN: 1757-4749