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Table 1 The characteristics of included studies

From: Associations between polymorphisms in IL-10 gene and the risk of viral hepatitis: a meta-analysis

First author, year Country Ethnicity Type of disease Sample size
Case/control
Genotypes (wtwt/wtmt/mtmt) p-value for HWE NOS score
Cases Controls
rs1800871 − 819 C/T
 Abbas 2009 Egypt Mixed HCV 99/62 44/43/12 30/27/5 0.752 7
 Afzal 2011 Pakistan Mixed HCV 89/99 16/66/7 15/81/3 < 0.001 7
 Barrett 2003 Ireland Caucasian HCV 92/66 49/38/5 40/22/2 0.621 7
 Basturk 2008 Turkey Caucasian HBV 50/60 33/15/2 29/22/9 0.175 7
 Chen 2007 China Asian HCV 72/180 36/32/4 94/73/13 0.819 7
 Cheong 2006 Taiwan Asian HBV 261/72 133/110/18 35/30/7 0.877 7
 Chuang 2009 Taiwan Asian HCV 97/46 47/38/12 25/19/2 0.491 7
 Constantini 2002 UK Caucasian HCV 546/354 NA NA NA 7
 Cunha 2018 Brazil Mixed HCV 132/98 59/54/19 46/41/11 0.685 7
 Khan 2014 India Mixed HCV 150/150 48/79/23 57/75/18 0.375 8
 Komatsu 2014 Japan Asian HBV 52/57 24/18/10 25/22/10 0.198 7
 Kusumoto 2006 Japan Asian HCV 346/114 156/160/30 59/46/9 0.994 7
 Li 2006 China Asian HBV 122/63 55/52/15 34/21/8 0.118 8
 Li 2015 China Asian HCV 379/364 176/167/36 178/158/28 0.383 8
 Maurya 2018 India Mixed Viral hepatitis 80/60 45/29/6 48/10/2 0.138 7
 Miyazoe 2002 Japan Asian HBV 213/52 153/56/4 38/13/1 0.927 7
 Moudi 2016 Iran Mixed HBV 221/200 40/163/18 30/162/8 <0.001 8
 Peng 2016 China Asian HBV 173/181 74/77/22 86/78/17 0.910 8
 Pereira 2008 Brazil Mixed HCV 128/94 50/60/18 36/48/10 0.305 8
 Persico 2006 Italy Caucasian HCV 120/110 60/54/6 53/51/6 0.159 8
 Qiu 2011 China Asian HBV 381/359 170/158/53 181/143/35 0.389 7
 Ribeiro 2007 Brazil Mixed HBV 30/41 17/12/1 20/16/3 0.935 7
 Sepahi 2014 Iran Mixed HCV 66/61 32/29/5 20/35/6 0.099 7
 Sodsai 2013 Thailand Asian HBV 131/142 47/74/10 67/59/16 0.584 8
 Sofian 2013 Iran Mixed HBV 64/31 26/27/11 16/11/4 0.358 7
 Srivastava 2014 India Mixed HBV 232/76 111/75/46 29/38/9 0.517 7
 Talaat 2014 Egypt Mixed HBV 115/119 69/40/6 62/52/5 0.143 7
 Tang 2012 China Asian HCV 607/885 259/286/62 407/382/96 0.653 8
 Tang 2015 China Asian HBV 207/56 114/59/34 25/17/14 0.006 7
 Vidigal 2002 USA Mixed HCV 78/36 53/16/9 20/13/3 0.672 7
 Wang 2012 China Asian HBV 123/525 40/66/17 205/251/69 0.567 7
 Xie 2008 China Asian HBV 186/151 78/93/15 73/68/10 0.266 7
 Yan 2009 China Asian HBV 712/414 334/291/87 231/150/33 0.219 8
 Yee 2001 USA Mixed HCV 49/50 24/19/6 36/14/0 0.250 7
 Zein 2004 USA Mixed HCV 58/80 36/17/5 49/25/6 0.279 7
 Zhang 2006 China Asian HBV 231/135 103/103/25 56/67/12 0.199 8
 Zhu 2015 China Asian HCV 143/36 56/66/21 18/14/4 0.616 7
rs1800872 − 592 C/A
 Abbas 2009 Egypt Mixed HCV 99/62 44/43/12 30/27/5 0.752 7
 Afzal 2011 Pakistan Mixed HCV 89/99 16/66/7 15/81/3 <0.001 7
 Ahmadabadi 2012 Iran Mixed HBV 57/100 31/24/2 42/55/3 0.003 8
 Barkhash 2017 Russia Caucasian HCV 143/203 80/52/11 121/78/4 0.032 7
 Barrett 2003 Ireland Caucasian HCV 92/66 49/38/5 40/22/2 0.621 7
 Basturk 2008 Turkey Caucasian HBV 50/60 33/15/2 29/22/9 0.175 7
 Cao 2016 China Asian HBV 241/254 88/104/49 100/112/42 0.267 7
 Chen 2007 China Asian HCV 72/180 36/32/4 93/74/13 0.741 7
 Chen 2010 China Asian HBV 304/361 150/124/30 173/145/43 0.144 7
 Cheong 2006 Taiwan Asian HBV 261/72 133/110/18 35/30/7 0.877 7
 Chuang 2009 Taiwan Asian HCV 143/134 73/56/14 65/59/10 0.495 7
 Constantini 2002 UK Caucasian HCV 546/354 NA NA NA 7
 Falleti 2007 Italy Caucasian HCV 50/96 29/17/4 61/31/4 0.980 7
 Gao 2009 China Asian HBV 69/74 31/29/9 34/31/9 0.641 7
 Gao 2009 China Asian HCV 55/74 29/20/6 34/31/9 0.641 7
 Gao 2016 China Asian HBV 180/85 46/108/26 26/31/18 0.029 8
 Jiang 2010 China Asian HBV 169/119 75/74/20 51/56/12 0.553 7
 Jiang 2013 China Asian HBV 250/134 60/130/60 40/62/32 0.409 7
 Jiang 2017 China Asian HBV 136/289 68/54/14 144/115/30 0.328 8
 Karatayli 2014 Turkey Caucasian HBV 116/53 63/41/12 29/20/4 0.831 7
 Khalil 2017 Egypt Mixed HCV 100/120 56/34/10 52/60/8 0.089 7
 Komatsu 2014 Japan Asian HBV 52/57 23/14/15 26/21/10 0.131 7
 Kusumoto 2006 Japan Asian HCV 346/114 156/160/30 59/46/9 0.994 7
 Li 2003 China Asian HBV 95/76 24/58/13 20/43/13 0.218 7
 Li 2006 China Asian HBV 122/63 55/52/15 34/21/8 0.119 8
 Li 2015 China Asian HCV 379/364 176/167/36 177/159/28 0.345 8
 Mangia 2004 Italy Caucasian HCV 270/136 156/90/24 81/55/9 0.003 7
 Maurya 2018 India Mixed Viral hepatitis 80/60 26/46/8 36/22/2 0.534 7
 Miyazoe 2002 Japan Asian HBV 213/52 95/91/27 26/20/6 0.483 7
 Moudi 2016 Iran Mixed HBV 221/200 36/168/17 31/157/12 <0.001 8
 Oleksyk 2005 USA Mixed HCV 856/398 NA NA NA 7
 Peng 2006 China Asian HBV 340/100 178/130/32 56/36/8 0.519 7
 Peng 2016 China Asian HBV 173/182 57/81/35 79/81/22 0.860 8
 Pereira 2008 Brazil Mixed HCV 128/94 50/60/18 36/48/10 0.305 8
 Persico 2006 Italy Caucasian HCV 120/110 60/54/6 53/51/6 0.159 8
 Qiu 2011 China Asian HBV 721/359 354/282/85 181/143/35 0.389 7
 Ramos 2012 Brazil Mixed HCV 161/17 58/60/43 8/5/4 0.120 7
 Ren 2017 China Asian HBV 250/134 60/130/60 40/62/32 0.409 7
 Ribeiro 2007 Brazil Mixed HBV 30/41 17/12/1 20/16/3 0.935 7
 Sepahi 2014 Iran Mixed HCV 66/61 32/29/5 20/35/6 0.099 7
 Shaker 2012 Egypt Mixed HCV 100/80 35/33/32 36/32/12 0.280 7
 Sheneef 2017 Egypt Mixed HCV 100/50 58/23/19 25/15/10 0.016 7
 Silva 2015 Brazil Mixed HCV 245/230 106/110/29 103/97/30 0.347 8
 Sodsai 2013 Thailand Asian HBV 131/142 47/74/10 67/59/16 0.584 8
 Sofian 2013 Iran Mixed HBV 86/31 31/42/13 16/11/4 0.358 7
 Srivastava 2014 India Mixed HBV 202/106 71/102/29 32/42/32 0.033 7
 Tang 2012 China Asian HCV 623/905 273/289/61 429/370/106 0.058 8
 Tseng 2006 Taiwan Asian HBV 344/184 169/148/27 90/75/19 0.567 7
 Vidigal 2002 USA Mixed HCV 78/36 53/16/9 23/10/3 0.239 7
 Wang 2008 China Asian HBV 335/165 132/169/34 80/64/21 0.156 7
 Wang 2012 China Asian HBV 123/525 43/63/17 206/250/69 0.615 7
 Wu 2010 China Asian HBV 175/153 82/67/26 54/77/22 0.515 7
 Xiang 2014 China Asian HBV 160/124 56/70/34 60/48/16 0.203 7
 Xie 2008 China Asian HBV 186/151 78/93/15 73/68/10 0.266 7
 Yan 2009 China Asian HBV 712/414 334/291/87 231/150/33 0.219 8
 Yee 2001 USA Mixed HCV 49/50 24/19/6 36/14/0 0.250 7
 Zein 2004 USA Mixed HCV 52/80 37/12/3 52/22/6 0.111 7
 Zhang 2006 China Asian HBV 396/135 189/168/39 56/67/12 0.199 8
 Zhu 2015 China Asian HCV 179/705 74/80/25 268/348/89 0.142 7
rs1800896 − 1082 G/A
 Abbas 2009 Egypt Mixed HCV 99/62 41/41/17 23/30/9 0.877 7
 Afzal 2011 Pakistan Mixed HCV 89/99 15/67/7 4/92/3 <0.001 7
 Barrett 2003 Ireland Caucasian HCV 92/66 20/47/25 20/36/10 0.344 7
 Basturk 2008 Turkey Caucasian HBV 50/60 17/22/11 38/16/6 0.049 7
 Bouzgarrou 2009 Tunisia Mixed HCV 100/103 38/43/19 42/49/12 0.687 7
 Cao 2016 China Asian HBV 241/254 88/112/41 116/111/27 0.954 7
 Chen 2007 China Asian HCV 72/180 70/2/0 176/4/0 0.880 7
 Chen 2010 China Asian HBV 304/361 264/37/3 319/40/2 0.544 7
 Cheong 2006 Taiwan Asian HBV 261/204 225/35/1 173/29/2 0.531 7
 Chuang 2009 Taiwan Asian HCV 143/133 132/11/0 124/9/0 0.686 7
 Conde 2013 Brazil Mixed HBV 53/97 27/20/6 47/41/9 0.989 7
 Constantini 2002 UK Caucasian HCV 546/354 NA NA NA 7
 Cunha 2018 Brazil Mixed HCV 132/98 56/54/22 44/38/16 0.124 7
 Dogra 2011 India Mixed HCV 70/70 38/22/10 42/25/3 0.764 7
 Falleti 2007 Italy Caucasian HCV 50/96 17/25/8 28/43/25 0.312 7
 Gao 2009 China Asian HBV 69/74 42/27/0 57/16/1 0.918 7
 Gao 2009 China Asian HCV 55/74 32/21/2 57/16/1 0.918 7
 Gao 2016 China Asian HBV 190/81 177/12/1 63/18/0 0.261 8
 Gao 2017 China Asian HBV + HCV 179/74 109/68/2 57/16/1 0.918 7
 Helal 2014 Egypt Mixed HCV 50/50 22/19/9 18/24/8 1.000 7
 Jiang 2013 China Asian HBV 250/134 189/58/3 102/26/6 0.019 7
 Karatayli 2014 Turkey Caucasian HBV 161/51 48/86/27 24/25/2 0.144 7
 Khan 2014 India Mixed HCV 150/150 64/67/19 85/55/10 0.785 8
 Knapp 2003 UK Caucasian HCV 577/94 183/250/144 27/54/13 0.090 7
 Kusumoto 2006 Japan Asian HCV 346/114 316/30/0 103/11/0 0.588 7
 Li 2006 China Asian HBV 62/63 48/14/0 52/11/0 0.448 8
 Li 2015 China Asian HCV 379/364 323/54/2 310/51/3 0.577 8
 Lio 2003 Italy Caucasian HCV 60/135 27/15/18 34/86/15 <0.0001 7
 Liu 2010 China Asian HBV 513/187 416/88/9 160/24/3 0.075 7
 Mangia 2004 Italy Caucasian HCV 270/145 120/110/40 56/66/23 0.631 7
 Maurya 2018 India Mixed Vral hepatitis 80/60 65/13/2 46/12/2 0.297 7
 Minton 2005 UK Caucasian HBV 284/54 77/123/84 18/25/11 0.669 7
 Miyazoe 2002 Japan Asian HBV 213/52 201/10/2 48/4/0 0.773 7
 Moudi 2016 Iran Mixed HBV 221/200 72/118/31 100/84/16 0.778 8
 Oleksyk 2005 USA Mixed HCV 856/398 NA NA NA 7
 Pár 2014 India Mixed HCV 672/92 214/333/125 48/32/12 0.087 8
 Pasha 2013 Egypt Mixed HCV 440/220 396/44/0 193/27/0 0.332 8
 Peng 2006 China Asian HBV 340/100 314/23/3 95/5/0 0.798 7
 Peng 2016 China Asian HBV 173/182 83/74/16 96/74/12 0.653 8
 Pereira 2008 Brazil Mixed HCV 128/94 56/55/17 38/43/13 0.881 8
 Persico 2006 Italy Caucasian HCV 120/110 43/51/26 36/56/18 0.628 8
 Ren 2017 China Asian HBV 250/134 189/58/3 102/26/6 0.019 7
 Ribeiro 2007 HBV Mixed HBV 30/41 12/16/2 16/20/5 0.743 7
 Sepahi 2014 Iran Mixed HCV 50/50 20/15/15 39/6/5 <0.001 7
 Sheneef 2017 Egypt Mixed HCV 100/50 26/43/31 10/35/5 0.003 7
 Silva 2015 Brazil Mixed HCV 245/230 106/110/29 119/83/28 0.029 8
 Sodsai 2013 Thailand Asian HBV 130/142 116/13/1 125/17/0 0.448 8
 Sofian 2013 Iran Mixed HBV 66/31 32/27/7 13/15/3 0.655 7
 Srivastava 2014 India Mixed HBV 232/76 96/73/63 32/43/1 0.002 7
 Talaat 2014 Egypt Mixed HBV 115/119 32/53/30 43/61/15 0.352 7
 Tang 2012 China Asian HCV 626/914 552/74/0 791/123/0 0.029 8
 Truelove 2008 USA Mixed HBV 45/76 15/24/6 38/32/6 0.837 7
 Vidigal 2002 USA Mixed HCV 78/36 29/22/27 16/14/6 0.346 7
 Wu 2010 China Asian HBV 175/153 148/27/0 122/30/1 0.561 7
 Xie 2008 China Asian HBV 186/151 164/22/0 128/22/1 0.959 7
 Yan 2009 China Asian HBV 732/414 644/68/0 389/25/0 0.526 8
 Yao 2015 China Asian HBV 318/318 125/141/52 152/135/31 0.898 7
 Zein 2004 USA Mixed HCV 52/80 17/18/17 28/32/20 0.087 7
 Zhang 2006 China Asian HBV 396/135 335/61/0 119/16/0 0.464 8
 Zhu 2005 China Asian HBV 167/123 115/45/7 81/37/5 0.766 7
  1. HBV hepatitis B virus infection, HCV hepatitis C virus infection, wt wild type, mt mutant type, HWE Hardy–Weinberg equilibrium, NOS Newcastle–ottawa scale, NA not available