Table 1 The characteristics of included studies
From: Associations between polymorphisms in IL-10 gene and the risk of viral hepatitis: a meta-analysis
First author, year | Country | Ethnicity | Type of disease | Sample size Case/control | Genotypes (wtwt/wtmt/mtmt) | p-value for HWE | NOS score | |
|---|---|---|---|---|---|---|---|---|
Cases | Controls | |||||||
rs1800871 − 819 C/T | ||||||||
Abbas 2009 | Egypt | Mixed | HCV | 99/62 | 44/43/12 | 30/27/5 | 0.752 | 7 |
Afzal 2011 | Pakistan | Mixed | HCV | 89/99 | 16/66/7 | 15/81/3 | < 0.001 | 7 |
Barrett 2003 | Ireland | Caucasian | HCV | 92/66 | 49/38/5 | 40/22/2 | 0.621 | 7 |
Basturk 2008 | Turkey | Caucasian | HBV | 50/60 | 33/15/2 | 29/22/9 | 0.175 | 7 |
Chen 2007 | China | Asian | HCV | 72/180 | 36/32/4 | 94/73/13 | 0.819 | 7 |
Cheong 2006 | Taiwan | Asian | HBV | 261/72 | 133/110/18 | 35/30/7 | 0.877 | 7 |
Chuang 2009 | Taiwan | Asian | HCV | 97/46 | 47/38/12 | 25/19/2 | 0.491 | 7 |
Constantini 2002 | UK | Caucasian | HCV | 546/354 | NA | NA | NA | 7 |
Cunha 2018 | Brazil | Mixed | HCV | 132/98 | 59/54/19 | 46/41/11 | 0.685 | 7 |
Khan 2014 | India | Mixed | HCV | 150/150 | 48/79/23 | 57/75/18 | 0.375 | 8 |
Komatsu 2014 | Japan | Asian | HBV | 52/57 | 24/18/10 | 25/22/10 | 0.198 | 7 |
Kusumoto 2006 | Japan | Asian | HCV | 346/114 | 156/160/30 | 59/46/9 | 0.994 | 7 |
Li 2006 | China | Asian | HBV | 122/63 | 55/52/15 | 34/21/8 | 0.118 | 8 |
Li 2015 | China | Asian | HCV | 379/364 | 176/167/36 | 178/158/28 | 0.383 | 8 |
Maurya 2018 | India | Mixed | Viral hepatitis | 80/60 | 45/29/6 | 48/10/2 | 0.138 | 7 |
Miyazoe 2002 | Japan | Asian | HBV | 213/52 | 153/56/4 | 38/13/1 | 0.927 | 7 |
Moudi 2016 | Iran | Mixed | HBV | 221/200 | 40/163/18 | 30/162/8 | <0.001 | 8 |
Peng 2016 | China | Asian | HBV | 173/181 | 74/77/22 | 86/78/17 | 0.910 | 8 |
Pereira 2008 | Brazil | Mixed | HCV | 128/94 | 50/60/18 | 36/48/10 | 0.305 | 8 |
Persico 2006 | Italy | Caucasian | HCV | 120/110 | 60/54/6 | 53/51/6 | 0.159 | 8 |
Qiu 2011 | China | Asian | HBV | 381/359 | 170/158/53 | 181/143/35 | 0.389 | 7 |
Ribeiro 2007 | Brazil | Mixed | HBV | 30/41 | 17/12/1 | 20/16/3 | 0.935 | 7 |
Sepahi 2014 | Iran | Mixed | HCV | 66/61 | 32/29/5 | 20/35/6 | 0.099 | 7 |
Sodsai 2013 | Thailand | Asian | HBV | 131/142 | 47/74/10 | 67/59/16 | 0.584 | 8 |
Sofian 2013 | Iran | Mixed | HBV | 64/31 | 26/27/11 | 16/11/4 | 0.358 | 7 |
Srivastava 2014 | India | Mixed | HBV | 232/76 | 111/75/46 | 29/38/9 | 0.517 | 7 |
Talaat 2014 | Egypt | Mixed | HBV | 115/119 | 69/40/6 | 62/52/5 | 0.143 | 7 |
Tang 2012 | China | Asian | HCV | 607/885 | 259/286/62 | 407/382/96 | 0.653 | 8 |
Tang 2015 | China | Asian | HBV | 207/56 | 114/59/34 | 25/17/14 | 0.006 | 7 |
Vidigal 2002 | USA | Mixed | HCV | 78/36 | 53/16/9 | 20/13/3 | 0.672 | 7 |
Wang 2012 | China | Asian | HBV | 123/525 | 40/66/17 | 205/251/69 | 0.567 | 7 |
Xie 2008 | China | Asian | HBV | 186/151 | 78/93/15 | 73/68/10 | 0.266 | 7 |
Yan 2009 | China | Asian | HBV | 712/414 | 334/291/87 | 231/150/33 | 0.219 | 8 |
Yee 2001 | USA | Mixed | HCV | 49/50 | 24/19/6 | 36/14/0 | 0.250 | 7 |
Zein 2004 | USA | Mixed | HCV | 58/80 | 36/17/5 | 49/25/6 | 0.279 | 7 |
Zhang 2006 | China | Asian | HBV | 231/135 | 103/103/25 | 56/67/12 | 0.199 | 8 |
Zhu 2015 | China | Asian | HCV | 143/36 | 56/66/21 | 18/14/4 | 0.616 | 7 |
rs1800872 − 592 C/A | ||||||||
Abbas 2009 | Egypt | Mixed | HCV | 99/62 | 44/43/12 | 30/27/5 | 0.752 | 7 |
Afzal 2011 | Pakistan | Mixed | HCV | 89/99 | 16/66/7 | 15/81/3 | <0.001 | 7 |
Ahmadabadi 2012 | Iran | Mixed | HBV | 57/100 | 31/24/2 | 42/55/3 | 0.003 | 8 |
Barkhash 2017 | Russia | Caucasian | HCV | 143/203 | 80/52/11 | 121/78/4 | 0.032 | 7 |
Barrett 2003 | Ireland | Caucasian | HCV | 92/66 | 49/38/5 | 40/22/2 | 0.621 | 7 |
Basturk 2008 | Turkey | Caucasian | HBV | 50/60 | 33/15/2 | 29/22/9 | 0.175 | 7 |
Cao 2016 | China | Asian | HBV | 241/254 | 88/104/49 | 100/112/42 | 0.267 | 7 |
Chen 2007 | China | Asian | HCV | 72/180 | 36/32/4 | 93/74/13 | 0.741 | 7 |
Chen 2010 | China | Asian | HBV | 304/361 | 150/124/30 | 173/145/43 | 0.144 | 7 |
Cheong 2006 | Taiwan | Asian | HBV | 261/72 | 133/110/18 | 35/30/7 | 0.877 | 7 |
Chuang 2009 | Taiwan | Asian | HCV | 143/134 | 73/56/14 | 65/59/10 | 0.495 | 7 |
Constantini 2002 | UK | Caucasian | HCV | 546/354 | NA | NA | NA | 7 |
Falleti 2007 | Italy | Caucasian | HCV | 50/96 | 29/17/4 | 61/31/4 | 0.980 | 7 |
Gao 2009 | China | Asian | HBV | 69/74 | 31/29/9 | 34/31/9 | 0.641 | 7 |
Gao 2009 | China | Asian | HCV | 55/74 | 29/20/6 | 34/31/9 | 0.641 | 7 |
Gao 2016 | China | Asian | HBV | 180/85 | 46/108/26 | 26/31/18 | 0.029 | 8 |
Jiang 2010 | China | Asian | HBV | 169/119 | 75/74/20 | 51/56/12 | 0.553 | 7 |
Jiang 2013 | China | Asian | HBV | 250/134 | 60/130/60 | 40/62/32 | 0.409 | 7 |
Jiang 2017 | China | Asian | HBV | 136/289 | 68/54/14 | 144/115/30 | 0.328 | 8 |
Karatayli 2014 | Turkey | Caucasian | HBV | 116/53 | 63/41/12 | 29/20/4 | 0.831 | 7 |
Khalil 2017 | Egypt | Mixed | HCV | 100/120 | 56/34/10 | 52/60/8 | 0.089 | 7 |
Komatsu 2014 | Japan | Asian | HBV | 52/57 | 23/14/15 | 26/21/10 | 0.131 | 7 |
Kusumoto 2006 | Japan | Asian | HCV | 346/114 | 156/160/30 | 59/46/9 | 0.994 | 7 |
Li 2003 | China | Asian | HBV | 95/76 | 24/58/13 | 20/43/13 | 0.218 | 7 |
Li 2006 | China | Asian | HBV | 122/63 | 55/52/15 | 34/21/8 | 0.119 | 8 |
Li 2015 | China | Asian | HCV | 379/364 | 176/167/36 | 177/159/28 | 0.345 | 8 |
Mangia 2004 | Italy | Caucasian | HCV | 270/136 | 156/90/24 | 81/55/9 | 0.003 | 7 |
Maurya 2018 | India | Mixed | Viral hepatitis | 80/60 | 26/46/8 | 36/22/2 | 0.534 | 7 |
Miyazoe 2002 | Japan | Asian | HBV | 213/52 | 95/91/27 | 26/20/6 | 0.483 | 7 |
Moudi 2016 | Iran | Mixed | HBV | 221/200 | 36/168/17 | 31/157/12 | <0.001 | 8 |
Oleksyk 2005 | USA | Mixed | HCV | 856/398 | NA | NA | NA | 7 |
Peng 2006 | China | Asian | HBV | 340/100 | 178/130/32 | 56/36/8 | 0.519 | 7 |
Peng 2016 | China | Asian | HBV | 173/182 | 57/81/35 | 79/81/22 | 0.860 | 8 |
Pereira 2008 | Brazil | Mixed | HCV | 128/94 | 50/60/18 | 36/48/10 | 0.305 | 8 |
Persico 2006 | Italy | Caucasian | HCV | 120/110 | 60/54/6 | 53/51/6 | 0.159 | 8 |
Qiu 2011 | China | Asian | HBV | 721/359 | 354/282/85 | 181/143/35 | 0.389 | 7 |
Ramos 2012 | Brazil | Mixed | HCV | 161/17 | 58/60/43 | 8/5/4 | 0.120 | 7 |
Ren 2017 | China | Asian | HBV | 250/134 | 60/130/60 | 40/62/32 | 0.409 | 7 |
Ribeiro 2007 | Brazil | Mixed | HBV | 30/41 | 17/12/1 | 20/16/3 | 0.935 | 7 |
Sepahi 2014 | Iran | Mixed | HCV | 66/61 | 32/29/5 | 20/35/6 | 0.099 | 7 |
Shaker 2012 | Egypt | Mixed | HCV | 100/80 | 35/33/32 | 36/32/12 | 0.280 | 7 |
Sheneef 2017 | Egypt | Mixed | HCV | 100/50 | 58/23/19 | 25/15/10 | 0.016 | 7 |
Silva 2015 | Brazil | Mixed | HCV | 245/230 | 106/110/29 | 103/97/30 | 0.347 | 8 |
Sodsai 2013 | Thailand | Asian | HBV | 131/142 | 47/74/10 | 67/59/16 | 0.584 | 8 |
Sofian 2013 | Iran | Mixed | HBV | 86/31 | 31/42/13 | 16/11/4 | 0.358 | 7 |
Srivastava 2014 | India | Mixed | HBV | 202/106 | 71/102/29 | 32/42/32 | 0.033 | 7 |
Tang 2012 | China | Asian | HCV | 623/905 | 273/289/61 | 429/370/106 | 0.058 | 8 |
Tseng 2006 | Taiwan | Asian | HBV | 344/184 | 169/148/27 | 90/75/19 | 0.567 | 7 |
Vidigal 2002 | USA | Mixed | HCV | 78/36 | 53/16/9 | 23/10/3 | 0.239 | 7 |
Wang 2008 | China | Asian | HBV | 335/165 | 132/169/34 | 80/64/21 | 0.156 | 7 |
Wang 2012 | China | Asian | HBV | 123/525 | 43/63/17 | 206/250/69 | 0.615 | 7 |
Wu 2010 | China | Asian | HBV | 175/153 | 82/67/26 | 54/77/22 | 0.515 | 7 |
Xiang 2014 | China | Asian | HBV | 160/124 | 56/70/34 | 60/48/16 | 0.203 | 7 |
Xie 2008 | China | Asian | HBV | 186/151 | 78/93/15 | 73/68/10 | 0.266 | 7 |
Yan 2009 | China | Asian | HBV | 712/414 | 334/291/87 | 231/150/33 | 0.219 | 8 |
Yee 2001 | USA | Mixed | HCV | 49/50 | 24/19/6 | 36/14/0 | 0.250 | 7 |
Zein 2004 | USA | Mixed | HCV | 52/80 | 37/12/3 | 52/22/6 | 0.111 | 7 |
Zhang 2006 | China | Asian | HBV | 396/135 | 189/168/39 | 56/67/12 | 0.199 | 8 |
Zhu 2015 | China | Asian | HCV | 179/705 | 74/80/25 | 268/348/89 | 0.142 | 7 |
rs1800896 − 1082 G/A | ||||||||
Abbas 2009 | Egypt | Mixed | HCV | 99/62 | 41/41/17 | 23/30/9 | 0.877 | 7 |
Afzal 2011 | Pakistan | Mixed | HCV | 89/99 | 15/67/7 | 4/92/3 | <0.001 | 7 |
Barrett 2003 | Ireland | Caucasian | HCV | 92/66 | 20/47/25 | 20/36/10 | 0.344 | 7 |
Basturk 2008 | Turkey | Caucasian | HBV | 50/60 | 17/22/11 | 38/16/6 | 0.049 | 7 |
Bouzgarrou 2009 | Tunisia | Mixed | HCV | 100/103 | 38/43/19 | 42/49/12 | 0.687 | 7 |
Cao 2016 | China | Asian | HBV | 241/254 | 88/112/41 | 116/111/27 | 0.954 | 7 |
Chen 2007 | China | Asian | HCV | 72/180 | 70/2/0 | 176/4/0 | 0.880 | 7 |
Chen 2010 | China | Asian | HBV | 304/361 | 264/37/3 | 319/40/2 | 0.544 | 7 |
Cheong 2006 | Taiwan | Asian | HBV | 261/204 | 225/35/1 | 173/29/2 | 0.531 | 7 |
Chuang 2009 | Taiwan | Asian | HCV | 143/133 | 132/11/0 | 124/9/0 | 0.686 | 7 |
Conde 2013 | Brazil | Mixed | HBV | 53/97 | 27/20/6 | 47/41/9 | 0.989 | 7 |
Constantini 2002 | UK | Caucasian | HCV | 546/354 | NA | NA | NA | 7 |
Cunha 2018 | Brazil | Mixed | HCV | 132/98 | 56/54/22 | 44/38/16 | 0.124 | 7 |
Dogra 2011 | India | Mixed | HCV | 70/70 | 38/22/10 | 42/25/3 | 0.764 | 7 |
Falleti 2007 | Italy | Caucasian | HCV | 50/96 | 17/25/8 | 28/43/25 | 0.312 | 7 |
Gao 2009 | China | Asian | HBV | 69/74 | 42/27/0 | 57/16/1 | 0.918 | 7 |
Gao 2009 | China | Asian | HCV | 55/74 | 32/21/2 | 57/16/1 | 0.918 | 7 |
Gao 2016 | China | Asian | HBV | 190/81 | 177/12/1 | 63/18/0 | 0.261 | 8 |
Gao 2017 | China | Asian | HBV + HCV | 179/74 | 109/68/2 | 57/16/1 | 0.918 | 7 |
Helal 2014 | Egypt | Mixed | HCV | 50/50 | 22/19/9 | 18/24/8 | 1.000 | 7 |
Jiang 2013 | China | Asian | HBV | 250/134 | 189/58/3 | 102/26/6 | 0.019 | 7 |
Karatayli 2014 | Turkey | Caucasian | HBV | 161/51 | 48/86/27 | 24/25/2 | 0.144 | 7 |
Khan 2014 | India | Mixed | HCV | 150/150 | 64/67/19 | 85/55/10 | 0.785 | 8 |
Knapp 2003 | UK | Caucasian | HCV | 577/94 | 183/250/144 | 27/54/13 | 0.090 | 7 |
Kusumoto 2006 | Japan | Asian | HCV | 346/114 | 316/30/0 | 103/11/0 | 0.588 | 7 |
Li 2006 | China | Asian | HBV | 62/63 | 48/14/0 | 52/11/0 | 0.448 | 8 |
Li 2015 | China | Asian | HCV | 379/364 | 323/54/2 | 310/51/3 | 0.577 | 8 |
Lio 2003 | Italy | Caucasian | HCV | 60/135 | 27/15/18 | 34/86/15 | <0.0001 | 7 |
Liu 2010 | China | Asian | HBV | 513/187 | 416/88/9 | 160/24/3 | 0.075 | 7 |
Mangia 2004 | Italy | Caucasian | HCV | 270/145 | 120/110/40 | 56/66/23 | 0.631 | 7 |
Maurya 2018 | India | Mixed | Vral hepatitis | 80/60 | 65/13/2 | 46/12/2 | 0.297 | 7 |
Minton 2005 | UK | Caucasian | HBV | 284/54 | 77/123/84 | 18/25/11 | 0.669 | 7 |
Miyazoe 2002 | Japan | Asian | HBV | 213/52 | 201/10/2 | 48/4/0 | 0.773 | 7 |
Moudi 2016 | Iran | Mixed | HBV | 221/200 | 72/118/31 | 100/84/16 | 0.778 | 8 |
Oleksyk 2005 | USA | Mixed | HCV | 856/398 | NA | NA | NA | 7 |
Pár 2014 | India | Mixed | HCV | 672/92 | 214/333/125 | 48/32/12 | 0.087 | 8 |
Pasha 2013 | Egypt | Mixed | HCV | 440/220 | 396/44/0 | 193/27/0 | 0.332 | 8 |
Peng 2006 | China | Asian | HBV | 340/100 | 314/23/3 | 95/5/0 | 0.798 | 7 |
Peng 2016 | China | Asian | HBV | 173/182 | 83/74/16 | 96/74/12 | 0.653 | 8 |
Pereira 2008 | Brazil | Mixed | HCV | 128/94 | 56/55/17 | 38/43/13 | 0.881 | 8 |
Persico 2006 | Italy | Caucasian | HCV | 120/110 | 43/51/26 | 36/56/18 | 0.628 | 8 |
Ren 2017 | China | Asian | HBV | 250/134 | 189/58/3 | 102/26/6 | 0.019 | 7 |
Ribeiro 2007 | HBV | Mixed | HBV | 30/41 | 12/16/2 | 16/20/5 | 0.743 | 7 |
Sepahi 2014 | Iran | Mixed | HCV | 50/50 | 20/15/15 | 39/6/5 | <0.001 | 7 |
Sheneef 2017 | Egypt | Mixed | HCV | 100/50 | 26/43/31 | 10/35/5 | 0.003 | 7 |
Silva 2015 | Brazil | Mixed | HCV | 245/230 | 106/110/29 | 119/83/28 | 0.029 | 8 |
Sodsai 2013 | Thailand | Asian | HBV | 130/142 | 116/13/1 | 125/17/0 | 0.448 | 8 |
Sofian 2013 | Iran | Mixed | HBV | 66/31 | 32/27/7 | 13/15/3 | 0.655 | 7 |
Srivastava 2014 | India | Mixed | HBV | 232/76 | 96/73/63 | 32/43/1 | 0.002 | 7 |
Talaat 2014 | Egypt | Mixed | HBV | 115/119 | 32/53/30 | 43/61/15 | 0.352 | 7 |
Tang 2012 | China | Asian | HCV | 626/914 | 552/74/0 | 791/123/0 | 0.029 | 8 |
Truelove 2008 | USA | Mixed | HBV | 45/76 | 15/24/6 | 38/32/6 | 0.837 | 7 |
Vidigal 2002 | USA | Mixed | HCV | 78/36 | 29/22/27 | 16/14/6 | 0.346 | 7 |
Wu 2010 | China | Asian | HBV | 175/153 | 148/27/0 | 122/30/1 | 0.561 | 7 |
Xie 2008 | China | Asian | HBV | 186/151 | 164/22/0 | 128/22/1 | 0.959 | 7 |
Yan 2009 | China | Asian | HBV | 732/414 | 644/68/0 | 389/25/0 | 0.526 | 8 |
Yao 2015 | China | Asian | HBV | 318/318 | 125/141/52 | 152/135/31 | 0.898 | 7 |
Zein 2004 | USA | Mixed | HCV | 52/80 | 17/18/17 | 28/32/20 | 0.087 | 7 |
Zhang 2006 | China | Asian | HBV | 396/135 | 335/61/0 | 119/16/0 | 0.464 | 8 |
Zhu 2005 | China | Asian | HBV | 167/123 | 115/45/7 | 81/37/5 | 0.766 | 7 |