Table 2 Meta-analyses results of IL-10 gene polymorphisms and viral hepatitis
From: Associations between polymorphisms in IL-10 gene and the risk of viral hepatitis: a meta-analysis
Variables | Sample size | Dominant comparison | Recessive comparison | Over-dominant comparison | Allele comparison | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
p value | OR (95% CI) | I2 statistic (%) | p value | OR (95% CI) | I2 statistic (%) | p value | OR (95% CI) | I2 statistic (%) | p value | OR (95% CI) | I2 statistic (%) | ||
rs1800871 − 819 C/T | |||||||||||||
Overall | 6835/5679 | 0.002 | 0.89 (0.82–0.96) | 28 | 0.004 | 1.21 (1.06–1.38) | 0 | 0.17 | 1.06 (0.98–1.14) | 24 | 0.0004 | 0.90 (0.85–0.95) | 27 |
Asian | 4436/3832 | 0.0001 | 0.84 (0.76–0.92) | 0 | 0.09 | 1.14 (0.98–1.33) | 0 | 0.005 | 1.14 (1.04–1.25) | 0 | 0.0002 | 0.88 (0.82–0.94) | 0 |
Caucasian | 808/590 | 0.63 | 1.13 (0.67–1.91) | 51 | 0.37 | 0.71 (0.33–1.51) | 39 | 0.93 | 1.02 (0.71–1.46) | 0 | 0.48 | 1.19 (0.73–1.93) | 62 |
HBV | 3504/2734 | 0.05 | 0.90 (0.80–1.00) | 38 | 0.03 | 1.21 (1.02–1.45) | 9 | 0.51 | 1.04 (0.93–1.16) | 36 | 0.02 | 0.91 (0.84-0.98) | 37 |
HCV | 3251/2885 | 0.05 | 0.89 (0.80–1.00) | 0 | 0.07 | 1.20 (0.99–1.45) | 0 | 0.36 | 1.05 (0.94–1.18) | 0 | 0.03 | 0.91 (0.83–0.99) | 0 |
rs1800872 − 592 C/A | |||||||||||||
Overall | 12121/9873 | 0.003 | 0.91 (0.86-0.97) | 25 | 0.06 | 1.09 (1.00–1.20) | 13 | 0.07 | 1.06 (0.99–1.12) | 30 | 0.003 | 0.93 (0.89–0.98) | 34 |
Asian | 7935/6880 | 0.0009 | 0.89 (0.83–0.95) | 9 | 0.20 | 1.07 (0.96–1.19) | 0 | 0.007 | 1.10 (1.03–1.18) | 29 | 0.004 | 0.93 (0.88–0.98) | 8 |
Caucasian | 1387/1078 | 0.70 | 0.96 (0.78–1.18) | 0 | 0.15 | 1.36 (0.89–2.08) | 34 | 0.39 | 0.91 (0.74–1.13) | 0 | 0.19 | 0.89 (0.76–1.06) | 41 |
HBV | 6900/4995 | 0.008 | 0.90 (0.83–0.97) | 26 | 0.43 | 1.05 (0.93–1.18) | 19 | 0.02 | 1.10 (1.02–1.19) | 31 | 0.04 | 0.94 (0.89–1.00) | 39 |
HCV | 5141/4818 | 0.35 | 0.96 (0.87–1.05) | 1 | 0.05 | 1.17 (1.00–1.37) | 1 | 0.64 | 0.98 (0.89–1.08) | 12 | 0.08 | 0.94 (0.87–1.01) | 14 |
rs1800896 − 1082 G/A | |||||||||||||
Overall | 13133/8862 | 0.02 | 0.87 (0.78–0.98) | 57 | <0.0001 | 1.60 (1.41–1.82) | 26 | 0.56 | 0.96 (0.85–1.09) | 60 | <0.0001 | 0.83 (0.76–0.90) | 55 |
Asian | 6452/4797 | 0.02 | 0.88 (0.79–0.98) | 49 | 0.48 | 1.12 (0.82–1.53) | 0 | 0.11 | 1.09 (0.98–1.22) | 40 | 0.19 | 0.90 (0.77–1.05) | 54 |
Caucasian | 2210/1165 | 0.65 | 0.92 (0.64–1.32) | 69 | 0.009 | 1.67 (1.14–2.46) | 54 | 0.22 | 0.80 (0.55–1.15) | 72 | 0.03 | 0.78 (0.62–0.98) | 64 |
HBV | 6227/4067 | 0.01 | 0.82 (0.70-0.96) | 51 | < 0.0001 | 1.73 (1.42–2.10) | 27 | 0.61 | 1.04 (0.89–1.21) | 51 | 0.002 | 0.81 (0.71–0.93) | 57 |
HCV | 6647/4661 | 0.52 | 0.94 (0.79–1.13) | 60 | < 0.0001 | 1.52 (1.29–1.80) | 33 | 0.14 | 0.87 (0.71–1.05) | 66 | 0.008 | 0.85 (0.75–0.96) | 51 |