Skip to main content

Table 2 Meta-analyses results of IL-10 gene polymorphisms and viral hepatitis

From: Associations between polymorphisms in IL-10 gene and the risk of viral hepatitis: a meta-analysis

Variables Sample size Dominant comparison Recessive comparison Over-dominant comparison Allele comparison
p value OR (95% CI) I2 statistic (%) p value OR (95% CI) I2 statistic (%) p value OR (95% CI) I2 statistic (%) p value OR (95% CI) I2 statistic (%)
rs1800871 − 819 C/T
 Overall 6835/5679 0.002 0.89 (0.82–0.96) 28 0.004 1.21 (1.06–1.38) 0 0.17 1.06 (0.98–1.14) 24 0.0004 0.90 (0.85–0.95) 27
 Asian 4436/3832 0.0001 0.84 (0.76–0.92) 0 0.09 1.14 (0.98–1.33) 0 0.005 1.14 (1.04–1.25) 0 0.0002 0.88 (0.82–0.94) 0
 Caucasian 808/590 0.63 1.13 (0.67–1.91) 51 0.37 0.71 (0.33–1.51) 39 0.93 1.02 (0.71–1.46) 0 0.48 1.19 (0.73–1.93) 62
 HBV 3504/2734 0.05 0.90 (0.80–1.00) 38 0.03 1.21 (1.02–1.45) 9 0.51 1.04 (0.93–1.16) 36 0.02 0.91 (0.84-0.98) 37
 HCV 3251/2885 0.05 0.89 (0.80–1.00) 0 0.07 1.20 (0.99–1.45) 0 0.36 1.05 (0.94–1.18) 0 0.03 0.91 (0.83–0.99) 0
rs1800872 − 592 C/A
 Overall 12121/9873 0.003 0.91 (0.86-0.97) 25 0.06 1.09 (1.00–1.20) 13 0.07 1.06 (0.99–1.12) 30 0.003 0.93 (0.89–0.98) 34
 Asian 7935/6880 0.0009 0.89 (0.83–0.95) 9 0.20 1.07 (0.96–1.19) 0 0.007 1.10 (1.03–1.18) 29 0.004 0.93 (0.88–0.98) 8
 Caucasian 1387/1078 0.70 0.96 (0.78–1.18) 0 0.15 1.36 (0.89–2.08) 34 0.39 0.91 (0.74–1.13) 0 0.19 0.89 (0.76–1.06) 41
 HBV 6900/4995 0.008 0.90 (0.83–0.97) 26 0.43 1.05 (0.93–1.18) 19 0.02 1.10 (1.02–1.19) 31 0.04 0.94 (0.89–1.00) 39
 HCV 5141/4818 0.35 0.96 (0.87–1.05) 1 0.05 1.17 (1.00–1.37) 1 0.64 0.98 (0.89–1.08) 12 0.08 0.94 (0.87–1.01) 14
rs1800896 − 1082 G/A
 Overall 13133/8862 0.02 0.87 (0.78–0.98) 57 <0.0001 1.60 (1.41–1.82) 26 0.56 0.96 (0.85–1.09) 60 <0.0001 0.83 (0.76–0.90) 55
 Asian 6452/4797 0.02 0.88 (0.79–0.98) 49 0.48 1.12 (0.82–1.53) 0 0.11 1.09 (0.98–1.22) 40 0.19 0.90 (0.77–1.05) 54
 Caucasian 2210/1165 0.65 0.92 (0.64–1.32) 69 0.009 1.67 (1.14–2.46) 54 0.22 0.80 (0.55–1.15) 72 0.03 0.78 (0.62–0.98) 64
 HBV 6227/4067 0.01 0.82 (0.70-0.96) 51 < 0.0001 1.73 (1.42–2.10) 27 0.61 1.04 (0.89–1.21) 51 0.002 0.81 (0.71–0.93) 57
 HCV 6647/4661 0.52 0.94 (0.79–1.13) 60 < 0.0001 1.52 (1.29–1.80) 33 0.14 0.87 (0.71–1.05) 66 0.008 0.85 (0.75–0.96) 51
  1. The values in italic represent there is statistically significant differences between cases and controls
  2. HBV Hepatitis B virus infection, HCV Hepatitis C virus infection, OR Odds ratio, CI Confidence interval, NA Not available