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Table 1 Clinical and bacterial characteristics of K. pneumoniae BSIs

From: Development of risk factor-based scoring system for detection of hypervirulent Klebsiella pneumoniae bloodstream infections

Characteristics Community-onset BSIs Hospital-onset BSIs p value*
N % N %
Patient demographics
 Median age, years (range) 72.6 69.3–75.8 64.4 61.3–67.4 0.0004
 Male gender 61 59.2 76 63.9 0.478
Underlying disease
 Biliary tract disease 35 34.0 17 14.3 0.0005
 Diabetes mellitus 33 32.0 27 22.7 0.118
 Malignancy
  Hematologic 5 4.9 19 16.0 0.008
  Solid organ 43 41.8 37 31.1 0.099
 Other 15 14.6 34 28.6 0.012
 None 5 4.9 0 0 0.015
Site of infection
 Liver abscess 10 9.7 0 0 0.0005
 Biliary tract infection 43 41.8 17 14.3 < 0.0001
 Other intra-abdominal infection 5 4.9 6 5.0 0.949
 Urinary tract infection 20 19.4 31 26.1 0.241
 Pneumonia 10 9.7 12 10.1 0.926
 Febrile neutropenia 3 2.9 22 18.5 0.0003
 Other/unknown 14 13.6 31 26.1 0.021
Antimicrobial treatment
 Penicillins 21 20.4 28 23.5 0.574
 Cephalosporins 44 42.7 37 31.1 0.073
 Carbapenems 36 35.0 49 41.2 0.341
 Other antimicrobials 0 0 3 2.5 0.105
 None 1 1.0 4 3.4 0.231
30-day survival (n = 213) 79 82.3 99 84.6 0.648
Bacterial phenotypes
 Capsular serotype
  K1 10 9.7 5 4.2 0.103
  K2 14 13.6 14 11.8 0.683
  Non-K1/K2 79 76.7 100 84.0 0.168
 Hypermucoviscosity 15 14.6 6 5.0 0.016
 Capsule-related gene (n = 133)
  magA gene 6/52 11.5 5/81 6.2 0.273
  rmpA gene 11/52 21.2 8/81 6.2 0.010
 Antimicrobial resistance
  ESBL-producer 2 1.9 22 18.5 < 0.001
  Carbapenem resistance 0 0 1 0.8 0.351
  1. *Pearson’s χ2-test