Table 1 Clinical and bacterial characteristics of K. pneumoniae BSIs
Characteristics | Community-onset BSIs | Hospital-onset BSIs | p value* | ||
|---|---|---|---|---|---|
N | % | N | % | ||
Patient demographics | |||||
Median age, years (range) | 72.6 | 69.3–75.8 | 64.4 | 61.3–67.4 | 0.0004 |
Male gender | 61 | 59.2 | 76 | 63.9 | 0.478 |
Underlying disease | |||||
Biliary tract disease | 35 | 34.0 | 17 | 14.3 | 0.0005 |
Diabetes mellitus | 33 | 32.0 | 27 | 22.7 | 0.118 |
Malignancy | |||||
Hematologic | 5 | 4.9 | 19 | 16.0 | 0.008 |
Solid organ | 43 | 41.8 | 37 | 31.1 | 0.099 |
Other | 15 | 14.6 | 34 | 28.6 | 0.012 |
None | 5 | 4.9 | 0 | 0 | 0.015 |
Site of infection | |||||
Liver abscess | 10 | 9.7 | 0 | 0 | 0.0005 |
Biliary tract infection | 43 | 41.8 | 17 | 14.3 | < 0.0001 |
Other intra-abdominal infection | 5 | 4.9 | 6 | 5.0 | 0.949 |
Urinary tract infection | 20 | 19.4 | 31 | 26.1 | 0.241 |
Pneumonia | 10 | 9.7 | 12 | 10.1 | 0.926 |
Febrile neutropenia | 3 | 2.9 | 22 | 18.5 | 0.0003 |
Other/unknown | 14 | 13.6 | 31 | 26.1 | 0.021 |
Antimicrobial treatment | |||||
Penicillins | 21 | 20.4 | 28 | 23.5 | 0.574 |
Cephalosporins | 44 | 42.7 | 37 | 31.1 | 0.073 |
Carbapenems | 36 | 35.0 | 49 | 41.2 | 0.341 |
Other antimicrobials | 0 | 0 | 3 | 2.5 | 0.105 |
None | 1 | 1.0 | 4 | 3.4 | 0.231 |
30-day survival (n = 213) | 79 | 82.3 | 99 | 84.6 | 0.648 |
Bacterial phenotypes | |||||
Capsular serotype | |||||
K1 | 10 | 9.7 | 5 | 4.2 | 0.103 |
K2 | 14 | 13.6 | 14 | 11.8 | 0.683 |
Non-K1/K2 | 79 | 76.7 | 100 | 84.0 | 0.168 |
Hypermucoviscosity | 15 | 14.6 | 6 | 5.0 | 0.016 |
Capsule-related gene (n = 133) | |||||
magA gene | 6/52 | 11.5 | 5/81 | 6.2 | 0.273 |
rmpA gene | 11/52 | 21.2 | 8/81 | 6.2 | 0.010 |
Antimicrobial resistance | |||||
ESBL-producer | 2 | 1.9 | 22 | 18.5 | < 0.001 |
Carbapenem resistance | 0 | 0 | 1 | 0.8 | 0.351 |