Bacterial species in gut | Effect on response to PD-1 therapy |
---|---|
Bifidobacterium longum + Bifidobacterium breve | Oral administration to melanoma-bearing mice led to decrease in tumor volume to the same degree at PD-1 therapy alone. Co-administration with PD-1 therapy led to an even greater reduction in tumor volume. |
Akkermansia muciniphila | Increased representation in the gut leads to a more robust response to PD-1 therapy in patients with melanoma, NSCLC and RCC due to increased production of IFN-gamma producing memory T cells |
Faecalibacterium prausnitzii | Increased representation in the gut leads to longer progression-free survival in melanoma patients via increasing the concentration of CTLs in the tumor microenvironment |