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Fig. 4 | Gut Pathogens

Fig. 4

From: Transcriptome changes and polymyxin resistance of acid-adapted Escherichia coli O157:H7 ATCC 43889

Fig. 4

Growth rate, antimicrobial resistance, and biofilm formation of acid-adapted and non-adapted cells. p < 0.05 (*), 0.01 (**), and 0.001 (***). a The absorbance of acid-adapted cells was fourfold higher at the lag phase than that of the non-adapted cells in tryptic soy broth. The maximum population density of acid-adapted cells was lower than that of non-adapted cells (p < 0.001) ■, acid-adapted cells; , non-adapted cells. b MIC of polymyxin B for ATCC 43889. ■, acid-adapted cells; , non-adapted cells. c MIC of colistin for ATCC 43889. ■, acid-adapted cells; , non-adapted cells. d Survival of Escherichia coli on MHA with polymyxin B (12,500 U/L). The number of polymyxin B-resistant acid-adapted cells was higher than that of non-adapted cells (p < 0.01). e Survival of E. coli on MHA with colistin (1 mg/L). The number of colistin-resistant acid-adapted cells was higher than that of non-adapted cells (p < 0.001). f Survival of E. coli in simulated gastric fluid for 3 h. The number of surviving acid-adapted cells were 1 log higher than that of non-adapted cells (p < 0.001). g Biofilm formation of cells incubated with polymyxin B. h Biofilm formation of cells incubated with colistin

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