Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease

Hu, Shijia; Png, Eileen; Gowans, Michelle; Ong, David E. H.; de Sessions, Paola Florez; Song, Jie; Nagarajan, Niranjan

doi:10.1186/s13099-021-00409-5

Gut Pathogens

Table 2 Species level differences between Crohn's disease and Control

From: Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease

Depleted in crohn's disease			Enriched in crohn's disease
Species	p-value	Adjusted p-value	Species	p-value	Adjusted p-value
Gut
Faecalibacterium prausnitzii*	< 0.001	0.010	Clostridium nexile*	< 0.001	0.038
Roseburia inulinivorans*	< 0.001	0.010	Ruminococcus gnavus*	0.001	0.043
Alistipes senegalensis*	< 0.001	0.029	Bifidobacterium breve	0.001	0.060
Bacteroides faecis	0.001	0.060	Escherichia unclassified	0.003	0.105
Coprococcus catus	0.002	0.083	Escherichia coli	0.004	0.115
Ruminococcus callidus	0.002	0.099	Anaerostipes unclassified	0.005	0.115
Eubacterium rectale	0.003	0.100	Streptococcus anginosus	0.005	0.115
Parabacteroides merdae	0.005	0.115	Streptococcus pasteurianus	0.005	0.115
Bacteroides vulgatus	0.006	0.125	Coprobacillus unclassified	0.009	0.149
Eubacterium eligens	0.007	0.140	Atopobium parvulum	0.010	0.149
Dorea longicatena	0.007	0.140	Fusobacterium nucleatum	0.010	0.149
Megamonas hypermegale	0.010	0.149	Blautia producta	0.021	0.208
Alistipes putredinis	0.010	0.149	Erysipelotrichaceae bacterium	0.021	0.208
Catenibacterium mitsuokai	0.010	0.149	Morganella morganii	0.021	0.208
Bacteroides coprocola	0.012	0.163	Streptococcus macedonicus	0.021	0.208
Paraprevotella unclassified	0.013	0.163	Proteus mirabilis	0.021	0.208
Coprococcus comes	0.013	0.163	Veillonella atypica	0.026	0.232
Peptostreptococcaceae unclassified	0.014	0.170	Acidaminococcus fermentans	0.041	0.268
Bacteroides plebeius	0.018	0.208	Acidaminococcus sp D21	0.041	0.268
Eubacterium ventriosum	0.021	0.208	Clostridium innocuum	0.041	0.268
Bacteroides stercoris	0.023	0.219	Lachnospiraceae bacterium	0.041	0.268
Alistipes finegoldii	0.024	0.222	Lactobacillus gasseri	0.041	0.268
Alistipes shahii	0.025	0.228	Lactobacillus mucosae	0.041	0.268
Bacteroides nordii	0.027	0.236	Peptostreptococcus anaerobius	0.041	0.268
Odoribacter splanchnicus	0.028	0.236	Prevotella histicola	0.041	0.268
Eubacterium siraeum	0.031	0.260	Scardovia wiggsiae	0.041	0.268
Holdemania unclassified	0.037	0.268	Streptococcus mutans	0.041	0.268
Lachnospiraceae bacterium 5_1_63FAA	0.038	0.268	Rothia dentocariosa	0.043	0.273
Barnesiella intestinihominis	0.049	0.297	Clostridium ramosum	0.048	0.297
Roseburia hominis	0.049	0.297
Saliva
Bacteroides uniformis	< 0.001	0.117	Human herpesvirus 4	0.002	0.117
Bacteroides dorei	0.001	0.117	Streptococcus anginosus	0.002	0.117
Haemophilus parainfluenzae	0.003	0.128	Streptococcus oligofermentans	0.002	0.117
Subdoligranulum unclassified	0.023	0.526	Streptococcus vestibularis	0.002	0.117
Prevotella salivae	0.033	0.526	Streptococcus cristatus	0.004	0.134
Prevotella intermedia	0.039	0.526	Peptostreptococcus stomatis	0.010	0.326
			Streptococcus salivarius	0.020	0.526
			Actinomyces sp. ICM47	0.021	0.526
			Actinomyces naeslundii	0.032	0.526
			Stomatobaculum longum	0.033	0.526
			Actinomyces georgiae	0.041	0.526
			Lactobacillus fermentum	0.041	0.526
			Olsenella_uli	0.041	0.526
			Oribacterium sp. Oral taxon 078	0.041	0.526
			Parvimonas micra	0.041	0.526
			Slackia unclassified	0.041	0.526
			Streptococcus peroris	0.046	0.564

*Adjusted p-value < 0.05

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