Table 4 Microbial pathways with LDA effect > 3
From: Ectopic gut colonization: a metagenomic study of the oral and gut microbiome in Crohn’s disease
Most common in control group | Most common in crohn's disease group | ||||
|---|---|---|---|---|---|
Pathway | LDA effect | P-value | Pathway | LDA effect | P-value |
Gut | |||||
PWY 6151 S-adenosyl-L-methioninecycle I | 3.550 | < 0.001 | ARGSYNBSUB PWY L-arginine biosynthesis II (acetylcycle) | 3.162 | 0.001 |
PWY 5097 L-lysine biosynthesis VI | 3.471 | < 0.001 | GLUTORN PWY L-ornithine biosynthesis | 3.084 | 0.001 |
PWY 5686 UMP biosynthesis | 3.434 | < 0.001 | ARGSYN PWY L-arginine biosynthesis I (via L-ornithine) | 3.077 | 0.006 |
PWY 2942 L-lysine biosynthesis III | 3.421 | 0.001 | PWY-7400 L-arginine biosynthesis IV (archaebacterial) | 3.059 | 0.008 |
PWY 6700 queuosine biosynthesis | 3.414 | 0.002 | PWY 6270 isoprene biosynthesis I | 3.058 | < 0.001 |
NONMEVIPP PWY methylerythritol phosphate pathway I | 3.414 | < 0.001 | PWY 7560 methylerythritol phosphate pathway II | 3.042 | < 0.001 |
PWY 6737 starch degradation V | 3.335 | 0.003 | GLYCOLYSIS glycolysis I from glucose-6-phosphate | 3.038 | < 0.001 |
PWY 7219 adenosine ribonucleotides de novo biosynthesis | 3.296 | 0.001 | PWY66 400 glycolysis VI (metazoan) | 3.023 | 0.001 |
PWY 6386 UDP N-acetylmuramoyl pentapeptide biosynthesis II (lysine containing) | 3.234 | 0.003 | PWY 5484 glycolysis II from fructose-6-phosphate | 3.017 | 0.000 |
PWY 7221 guanosine ribonucleotides de novo biosynthesis | 3.219 | 0.004 | |||
PEPTIDOGLYCANSYN PWY peptidoglycan biosynthesis I (meso-diaminopimelate containing) | 3.212 | 0.003 | |||
ILEUSYN PWY L-isoleucine biosynthesis I (from threonine) | 3.212 | 0.006 | |||
VALSYN PWY L-valine biosynthesis | 3.212 | 0.006 | |||
PWY 6387 UDP N-acetylmuramoyl pentapeptide biosynthesis I (meso-diaminopimelate containing) | 3.170 | 0.003 | |||
BRANCHED CHAIN AA SYN PWY superpathway of branched aminoacid biosynthesis | 3.132 | 0.008 | |||
GALACTUROCAT PWY D-galacturonate degradation I | 3.113 | < 0.001 | |||
PWY 6897 thiamin salvage II | 3.104 | 0.001 | |||
PWY 7111 pyruvate fermentation to isobutanol engineered | 3.098 | 0.015 | |||
PWY 5973 cis-vaccenate biosynthesis | 3.096 | < 0.001 | |||
GALACT GLUCUROCAT PWY superpathway of hexuronide and hexuronate degradation | 3.087 | 0.001 | |||
GLUCUROCAT PWY superpathway of beta D-glucuronide and D-glucuronate degradation | 3.078 | 0.001 | |||
PWY 5103 L-isoleucine biosynthesis III | 3.062 | 0.012 | |||
PWY 6507 4-deoxy-L-threo-hex-4-enopyranuronate degradation | 3.040 | 0.001 | |||
PWY 7242 D-fructuronate degradation | 3.019 | 0.003 | |||
Saliva | |||||
FASYN INITIAL PWY superpathway of fatty acid biosynthesis initiation (E-coli) | 3.036 | 0.002 | PWY66 409 superpathway of purine nucleotide salvage | 3.035 | 0.018 |