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Table 1 Estimates of evolutionary divergence between patients’ HIV-1 proviral DNA sequences

From: Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy

 

Patient 5A

Patient 10

Patients 5A + 10

Median [min–max]

Mean

Median [min–max]

Mean

Median [min–max]

Mean

GALT

 NGS

0.030 [0–0.189]

0.029

0.016 [0–0.098]

0.016

nd

nd

 SGS

0.055 [0–0.088]

0.047

0.005 [0–0.013]

0.005

nd

nd

 NGS + SGS

0.061 [0–0.119]

0.054

0.011 [0–0.065]

0.012

nd

nd

PBMC

 NGS

0.053 [0–0.145]

0.051

0.013 [0–0.061]

0.013

nd

nd

 SGS

0.047 [0–0.122]

0.051

0.013 [0–0.030]

0.013

nd

nd

 NGS + SGS

0.065 [0.013–0,132]

0.065

0.016 [0–0.057]

0.017

nd

nd

GALT + PBMC

 NGS

0.053 [0.008–0.143]

0.054

0.022 [0.003–0.095]

0.022

0.08 [0.047–0.214]

0.085

  1. Evolutionary divergences are based on the number of base substitutions per site among RT NGS and/or SGS sequences obtained from GALT and/or PBMC proviral DNA of patients 5A and 10
  2. nd not done, RT reverse transcriptase, GALT gut associated lymphoid tissue, PBMC peripheral blood mononuclear cells, NGS next generation sequencing, SGS single genome sequencing
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Gut Pathogens

ISSN: 1757-4749