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Table 1 Estimates of evolutionary divergence between patients’ HIV-1 proviral DNA sequences

From: Phylogenetic analysis of HIV-1 archived DNA in blood and gut-associated lymphoid tissue in two patients under antiretroviral therapy

  Patient 5A Patient 10 Patients 5A + 10
Median [min–max] Mean Median [min–max] Mean Median [min–max] Mean
GALT
 NGS 0.030 [0–0.189] 0.029 0.016 [0–0.098] 0.016 nd nd
 SGS 0.055 [0–0.088] 0.047 0.005 [0–0.013] 0.005 nd nd
 NGS + SGS 0.061 [0–0.119] 0.054 0.011 [0–0.065] 0.012 nd nd
PBMC
 NGS 0.053 [0–0.145] 0.051 0.013 [0–0.061] 0.013 nd nd
 SGS 0.047 [0–0.122] 0.051 0.013 [0–0.030] 0.013 nd nd
 NGS + SGS 0.065 [0.013–0,132] 0.065 0.016 [0–0.057] 0.017 nd nd
GALT + PBMC
 NGS 0.053 [0.008–0.143] 0.054 0.022 [0.003–0.095] 0.022 0.08 [0.047–0.214] 0.085
  1. Evolutionary divergences are based on the number of base substitutions per site among RT NGS and/or SGS sequences obtained from GALT and/or PBMC proviral DNA of patients 5A and 10
  2. nd not done, RT reverse transcriptase, GALT gut associated lymphoid tissue, PBMC peripheral blood mononuclear cells, NGS next generation sequencing, SGS single genome sequencing