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Table 8 Amino acid polymorphisms in the sequence flanking the EPIYA motifs in 86 ABD subtypes

From: Diversity of 3′ variable region of cagA gene in Helicobacter pylori strains isolated from Chinese population

Disease 893 894 900 906 909 910 963 Total
N S  ~  E T  ~  A/N Q K E T A A V A T V/I R Q L
CG 43 (86) 3 (6) 4 (8) 32 (64) 12 (24) 4 (8) 2 (4) 29 (58) 20 (40) 1 (2) 32 (64) 18 (36) 28 (56) 22 (44) 34 (68) 15 (30) 1 (2) 34 (68) 15 (30) 1 (2) 50
GC 12 (63.2) 0 (0) 7 (36.8) * 2 (10.5) 9 (47.4) 7 (36.8) c 1 (5.3) 14 (73.7) 5 (26.3) 0 (0) 10 (52.6) 9 (47.4) 10 (52.6) 9 (47.4) 12 (63.2) 7 (36.8) 0 (0) 12 (63.2) 7 (36.8) 0 (0) 19
GU 8 (100) 0 (0) 0 (0) 5 (62.5) 2 (25) 0 (0) 1 (12.5) 8 (100) 0 (0) 0 (0) 5 (62.5) 3 (37.5) 6 (75) 2 (25) 5 (62.5) 3 (37.5) 0 (0) 7 (87.5) 1 (12.5) 0 (0) 8
DU 4 (80) 1 (20) 0 (0) 4 (80) 0 (0) 0 (0) 1 (20) 5 (100) 0 (0) 0 (0) 2 (40) 3 (60) 3 (60) 2 (40) 4 (80) 1 (20) 0 (0) 3 (60) 2 (40) 0 (0) 5
MALT lymphoma 3 (75) 1 (25) 0 (0) 3 (75) 1 (25) 0 (0) 0 (0) 2 (50) 2 (50) 0 (0) 2 (50) 2 (50) 3 (75) 1 (25) 2 (50) 1 (25) 1 (25) 3 (75) 1 (25) 0 (0) 4
Total 70 (81.4) 5 (5.8) 11 (12.8) 46 (53.5) 24 (27.9) 11 (12.8) 5 (5.8) 58 (67.4) 27 (31.4) 1 (1.2) 51 (59.3) 35 (40.7) 50 (58.1) 36 (41.9) 57 (66.3) 27 (31.4) 2 (2.3) 59 (68.6) 26 (30.2) 1 (1.2) 86
  1. Amino acid polymorphisms in the sequence flanking the EPIYA motifs in 86 ABD subtypes strains isolated from Chinese population. N, asparagine; S, serine; E, glutamic acid; T, threonine; A, alanine; Q, glutamine; K, lysine; V, valine; I, isoleucine; R, arginine; L, Leucine. Wavy lines indicate gap. Numbers in parentheses are percentages. * The absence of amino acids 893 and 894 was significantly associated with GC (P < 0.01). The Glu deletion or substituted by other amino acids at residue 894, such as threonine (Thr) or asparagine (Asn), was significantly associated with GC (P < 0.05)