A re-testing range is recommended for 13C- and 14C-urea breath tests for Helicobacter pylori infection in China

Table 3 Diagnostic performance of the ¹³C-UBT and ¹⁴C-UBT with optimal cutoff values for H. pylori positivity

Method	Histology			Sens (%)	Spec (%)	Acc (%)	FPR (%)	FNR (%)
Method		+	–	95%CI	95%CI	95%CI	95%CI	95%CI
¹³C-UBT	+	120	14	83.9	81.1	82.9	18.9	16.1
¹³C-UBT	–	23	60	76.6–89.3	70.0–88.9	77.4–87.4	11.1–30.0	10.7–23.4
¹⁴C-UBT	+	158	12	82.3	84	82.8	16	17.7
¹⁴C-UBT	–	34	63	76.0–87.3	73.3–91.1	77.8–86.9	8.9–26.7	12.7–24.0

Based on the maximum Youden index method, the optimal cutoff values for H. pylori positivity were 10.4% DOB and 238 DPM for the ¹³C-UBT and ¹⁴C-UBT, respectively
UBT urea breath test, Sens sensitivity, Spec specificity, Acc accuracy, FPR false positive rate, FNR false negative rate, CI confidence interval

ISSN: 1757-4749