Fig. 2

WT mice transferred with gut microbiota of Dock2^−/− mice have more bacterial load, shorter colon length, and more severe intestinal inflammation than WT mice transferred with WT mouse gut microbiota. A Schematic diagram of gut microbiota transfer experiments. WT mice were treated with streptomycin and transferred with WT or Dock2^−/− mouse gut microbiota, then infected with C. rodentium. Mouse feces were collected to measure bacterial load on days 4, 10, 14, 17, and 21. Mice were sacrificed on day 21 and colon lengths were measured. B C. rodentium bacterial load. C Colon length on day 21. D, E H & E staining photograph of colonic tissues. Scale bar 50 μm. WT mice n = 6; Dock2^−/− mice n = 5. * p < 0.05, *** p < 0.001. Data were presented as mean ± SEM. Results were representative of two independent experiments