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Table 1 Demographic and clinical characteristics of study participants

From: Relationship between gut microbiome diversity and hepatitis B viral load in patients with chronic hepatitis B

Characteristics

Healthy control

Chronic hepatitis B

p valueA, B

HBV DNA IU/mL

p valueA, B1

p valueA, B2

p valueB1, B2

 < 2000

 ≥ 2000

Group A

Group B

Group B1

Group B2

Number

57

57

 

40

17

   

Age (years)*

41.7 (7.91)

49.5 (9.64)

 < 0.001

51.3 (9.01)

45.2 (9.9)

 < 0.001

0.132

0.039

Male (%)

23 (40.4)

37 (64.9)

0.009

27 (67.5)

10 (58.8)

0.008

0.179

0.530

Current smoker (%)

1 (1.8)

8 (14)

 < 0.001

4 (10%)

4 (23.5)

 < 0.001

 < 0.001

0.324

BMI (kg/m2)*

22.93 (3.11)

23.49 (3.05)

0.326

23.74 (2.96)

22.91 (3.27)

0.196

0.983

0.372

HBeAg (%)

6 (10.5)

0

6 (35.3)

 < 0.001

HbeAb (%)

49 (86.0)

39 (97.5)

10 (58.8)

 < 0.001

Previous antiviral agents (%)

3 (5.3)

0

3 (17.6)

0.023

Lab findings (mean, SD)

 WBC

6116 (1407)

5389 (1441)

0.007

5443 (1566)

5261 (1125)

0.029

0.025

0.667

 Platelet

273,000 (59,060)

214,000 (51,740)

 < 0.001

214,000 (54,330)

216,000 (46,600)

 < 0.001

 < 0.001

0.913

 HbA1c

5.46 (0.28)

5.46 (0.38)

0.962

5.46 (0.33)

5.46 (0.51)

0.930

0.979

0.953

 Total bilirubin

0.68 (0.25)

0.91 (0.39)

 < 0.001

0.92 (0.39)

0.89 (0.40)

 < 0.001

0.052

0.814

 AST

21.18 (6.30)

23.86 (8.96)

0.067

22.98 (8.3)

25.94 (10.33)

0.228

0.086

0.304

 ALT

22.93 (14.02)

27.51 (24.13)

0.218

25.85 (25.11)

31.41 ( 21.84)

0.466

0.146

0.407

Lipid profile (mean, SD)

 Total cholesterol

190.18 (34.14)

182.19 (32.64)

0.205

182.48 (32.62)

181.53 (33.67)

0.268

0.361

0.923

 LDL-cholesterol

128.39 (33.83)

117.79 (28.50)

0.075

120.46 (28.52)

111.65 (28.34)

0.233

0.068

0.294

 HDL-cholesterol

63.28 (15.83)

57.41 (17.35)

0.063

53.23 (13.83)

67.00 (20.97)

0.002

0.434

0.021

  1. The χ2 test or Fisher’s exact test was used to compare groups A and B, A and B1, and B1 and B2
  2. *Values are presented as mean (standard deviation)
  3. Values are presented as numbers of 56 and values of 39
  4. SD standard deviation, LDL low-density lipoprotein, HDL high-density lipoprotein