Table 1 Clinic and laboratory characteristics of healthy subjects and HFMD patients

Gender (female/male)

28/37

29/36

28/37

Age (months)

41.42 ± 15.44

39.75 ± 23.81

27.57 ± 15.53***

EV-A71 positive, n (%)

–

65 (100)

65 (100)

Typical rashes^a, n (%)

–

55 (84.62)

56 (86.15)

Hands

–

50 (76.92)

56 (86.15)

Feet

–

49 (75.38)

53 (81.54)

Mouth

–

42 (64.62)

50 (76.92)

Buttock

–

19 (29.23)

26 (40.00)

Atypical rashes^b, n (%)

–

7 (10.77)

1 (1.54)*

Herpangina, n (%)

–

14 (21.54)

42 (64.62)**

Cardiovascular disorders, n (%)

–

–

4 (6.15)

Neurological disorders, n (%)

–

–

51 (78.46)

Pulmonary disorders, n (%)

–

–

19 (29.23)

Heart rate (/min)

123.5 ± 15.23

127.12 ± 18.37

144.62 ± 18.04***

Body temperature (°C)

37.45 ± 0.85

37.45 ± 0.37

38.38 ± 0.62***

WBC count (10⁹/L)

7.43 ± 1.66

8.78 ± 1.78

12.01 ± 3.42***

Lymphocyte count (10⁹/L)

3.22 ± 1.16

3.65 ± 1.40

4.23 ± 3.28

Monocyte count (10⁹/L)

0.54 ± 0.25

0.57 ± 0.24

0.81 ± 0.62**

Platelet count (10⁹/L)

239.37 ± 53.62

254.92 ± 49.27

277.37 ± 57.85**

CK (U/L)

102.37 ± 47.83

106.64 ± 52.45

112.23 ± 104.35

ALT (IU/L)

22.20 ± 6.15

23.37 ± 8.53

25.53 ± 13.28

AST (IU/L)

32.53 ± 15.36

33.53 ± 17.63

36.35 ± 20.25

LDH (U/L)

261.24 ± 46.53

276.25 ± 54.53

292.43 ± 78.53

Sampling time (d)^c

–

2.51 ± 0.82

2.77 ± 0.91