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Table 1 Top 20 candidate genes detected by TWAS in P/A and AB models

From: Transcriptome-wide association study identified candidate genes associated with gut microbiota

Gene

Tissue

Microbiota trait

Z

P

P/A-HB phenotype

 DNAJC9-AS1

Transverse colon

G_Ruminococcus

− 2.28

4.66 × 10–154

 CCDC36

Sigmoid colon

F_Enterococcaceae

− 2.22

6.46 × 10–130

 RP11-804H8.6

Sigmoid colon

F_Enterobacteriaceae

2.02

1.19 × 10–55

 TOB2P1

Sigmoid colon

F_Enterococcaceae

2.02

1.94 × 10–50

 ARHGAP1

Transverse colon

C_Gammaproteobacteria

1.96

4.85 × 10–44

 RP11-697N18.3

Transverse colon

F_Peptostreptococcaceae

2.54

3.91 × 10–33

 KCNIP3

Transverse colon

F_Veillonellaceae

1.97

8.35 × 10–33

 C3orf18

Sigmoid colon

C_Deltaproteobacteria

− 2.34

3.61 × 10–27

 C3orf18

Sigmoid colon

F_Enterobacteriaceae

− 2.07

5.68 × 10–22

 AC011330.5

Sigmoid colon

G_Clostridium_sensu_stricto

− 2.19

3.47 × 10–21

 RNF138P1

Sigmoid colon

G_Gemmiger

2.029

1.56 × 10–19

 ARIH2

Transverse colon

G_Coprococcus

2.57

3.39 × 10–18

 ELMO3

Transverse colon

G_Collinsella

− 2.33

1.02 × 10–16

 RP11-344N10.5

Sigmoid colon

G_Bifidobacterium

− 2.04

1.09 × 10–16

 WDR6

Sigmoid colon

G_Coprococcus

− 2.07

1.10 × 10–16

 CYP1A1

Transverse colon

G_Paraprevotella

2.30

2.60 × 10–15

 PROM2

Sigmoid colon

G_F_Coriobacteriaceae

2.65

1.74 × 10–13

 CYP1A1

Transverse colon

G_F_Porphyromonadaceae

2.28

9.01 × 10–13

 FBXO41

Transverse colon

G_Lactococcus

− 2.44

4.30 × 10–12

 PROM2

Sigmoid colon

G_F_Rhodospirillaceae

2.07

3.46 × 10–11

AB-RNT phenotype

 RP3-462E2.5

Transverse colon

G_Sporobacter

2.243

3.53 × 10–98

 WDR6

Sigmoid colon

G_Butyrivibrio

2.50

1.24 × 10–64

 ARIH2

Transverse colon

G_P_Proteobacteria

− 3.33

2.18 × 10–63

 TOB2P1

Sigmoid colon

G_Ruminococcus2

2.01

2.72 × 10–29

 IGKV6-21

Transverse colon

G_Collinsella

2.16

3.56 × 10–26

 C3orf18

Transverse colon

F_Enterobacteriaceae

− 2.77

3.09 × 10–24

 C3orf18

Sigmoid colon

C_Gammaproteobacteria

− 2.00

4.03 × 10–22

 FBXO41

Transverse colon

G_Clostridium_XlVa

− 2.60

1.47 × 10–21

 IGKV6-21

Transverse colon

G_P_Bacteroidetes

− 2.16

3.58 × 10–21

 RP11-10C24.3

Sigmoid colon

G_Sutterella

2.97

1.07 × 10–19

 C3orf18

Transverse colon

C_Gammaproteobacteria

− 2.14

7.08 × 10–19

 ZNF33A

Transverse colon

G_P_Bacteroidetes

2.50

8.09 × 10–19

 SLC33A1

Sigmoid colon

G_Sutterella

− 2.28

1.10 × 10–17

 DNAJB12

Transverse colon

P_Proteobacteria

2.59

1.19 × 10–17

 CENPE

Sigmoid colon

F_Veillonellaceae

2.20

2.30 × 10–17

 MUTYH

Transverse colon

G_Prevotella

− 2.39

2.74 × 10–17

 RP11-365H22.2

Transverse colon

O_Burkholderiales

2.08

3.75 × 10–16

 SIL1

Transverse colon

G_Streptococcus

2.31

1.10 × 10–15

 GINM1

Sigmoid colon

G_F_Lachnospiraceae

2.50

2.80 × 10–15

 RP11-365H22.2

Transverse colon

G_P_Firmicutes

1.97

2.26 × 10–14