Table 4 Top 10 significant GO and KEGG pathways for microbial traits
From: Transcriptome-wide association study identified candidate genes associated with gut microbiota
GeneSet | Microbial trait | FDR P |
|---|---|---|
GO term | ||
 GO_NUCLEOSIDE_DIPHOSPHATASE_ACTIVITY | G_Butyrivibrio_RNT | 1.30 × 10–4 |
 GO_CONDENSED_CHROMOSOME_CENTROMERIC_REGION | G_Acidaminococcus_HB | 1.17 × 10–3 |
 GO_KINETOCHORE | G_Acidaminococcus_HB | 1.17 × 10–3 |
 GO_CHROMOSOMAL_REGION | G_Acidaminococcus_HB | 1.39 × 10–3 |
 GO_SPECTRIN_BINDING | O_Burkholderiales_RNT | 1.69 × 10–3 |
 GO_CHROMOSOME_CENTROMERIC_REGION | G_Acidaminococcus_HB | 2.55 × 10–3 |
 GO_VACUOLE | F_Enterobacteriaceae_RNT | 2.84 × 10–3 |
 GO_OXIDOREDUCTASE_ACTIVITY_AC TING_ON_PAIRED_DONORS_WITH_INCORPORATION _OR_REDUCTION_OF_MOLECULAR_OXYGEN_REDUCED _FLAVIN_OR_FLAVOPROTEIN_AS_ONE_DONOR_AND _INCORPORATION_OF_ONE_ATOM_OF_OXYGEN | G_unclassified_F_Porphyromonadaceae_HB | 3.62 × 10–3 |
 GO_STEROID_HYDROXYLASE_ACTIVITY | G_unclassified_F_Porphyromonadaceae_HB | 3.62 × 10–3 |
 GO_CONDENSED_CHROMOSOME | G_unclassified_F_Porphyromonadaceae_HB | 3.73 × 10–3 |
KEGG pathway | ||
 KEGG_RETINOL_METABOLISM | G_unclassified_F_Porphyromonadaceae_HB | 3.35 × 10–3 |
 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 | G_unclassified_F_Porphyromonadaceae_HB | 3.35 × 10–3 |
 KEGG_PURINE_METABOLISM | F_Veillonellaceae_HB | 7.35 × 10–3 |
 KEGG_METABOLISM_OF_XENOBIOTICS_BY_CYTOCHROME_P450 | Div_Shannon_RNT | 7.36 × 10–3 |
 KEGG_FC_GAMMA_R_MEDIATED_PHAGOCYTOSIS | O_Selenomonadales_RNT | 1.28 × 10–2 |
 KEGG_NEUROACTIVE_LIGAND_RECEPTOR_INTERACTION | F_Desulfovibrionaceae_RNT | 1.48 × 10–2 |
 KEGG_PYRIMIDINE_METABOLISM | F_Veillonellaceae_HB | 2.07 × 10–2 |
 KEGG_JAK_STAT_SIGNALING_PATHWAY | F_Enterococcaceae_RNT | 2.60 × 10–2 |
 KEGG_LYSOSOME | F_Enterobacteriaceae_RNT | 2.81 × 10–2 |
 KEGG_RENIN_ANGIOTENSIN_SYSTEM | G_Anaerostipes_RNT | 3.16 × 10–2 |