Myxopyronin B inhibits growth of a Fidaxomicin-resistant Clostridioides difficile isolate and interferes with toxin synthesis

Table 1 Minimal inhibitory concentrations Rifaximin and Myxopyronin B against C. difficile

	630	1780	R20291	RT126	RT78
Rif	0.002	0.004	0.004	0.004	0.004
MyxB	8	0.125	4	0.5	0.5

Minimal inhibitory concentrations of the reference antibiotic Rifaximin (Rif) and the natural product Myxopyronin B (MyxB) were determined against five different C. difficile strains in serial broth dilution assays after 24 h of growth in BHIS. Concentrations are given in µg/ml and are means of three biological replicates.

ISSN: 1757-4749