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Table 3 Impact of treatment on known bacterial causes of diarrhoea

From: Impact of azithromycin mass drug administration on the antibiotic-resistant gut microbiome in children: a randomized, controlled trial

Bacteria

Ba

SEb

Adjusted p-value

Aeromonas

− 0.077

0.162

0.9668

Campylobacter jejuni

0.717

0.289

0.2271

Escherichia coli

1.047

0.391

0.1599

Non-typhoid Salmonellac

0.255

0.186

0.7767

Shigella

0.114

0.599

0.9910

Any pathogen

1.001

0.334

0.0845

  1. The GEMS study specifically identified enteroaggregative (EAEC), enteropathogenic (EPEC) and enterotoxigenic (ETEC) E. coli strains as primary causes of diarrhoea. More than 90% of E. coli reads here could not be classified at the strain-level; approximately 300,000 E. coli reads could be classified to the strain level and were analysed further. All three pathogens showed a trend towards increased abundance in treated children, significantly for EPEC (p = 0.0001, EAEC; p = 0.2970, ETEC; p = 0.8835)
  2. aβ = regression coefficient
  3. bSE = standard error
  4. cthe only non-typhoid Salmonella identified was S. enterica