Virulence genes expression profiling of different Shigella flexneri serotypes in response to sub-inhibitory concentrations of azithromycin and ciprofloxacin

Table 5 Frequency and pattern of multidrug resistance phenotype among S. flexneri isolates in children with community acquired diarrhea

MDR phenotypes	Serotype 1b	Serotype 2a	Serotype 2b	Serotype 3a	Seroytpe 4a	Seroytpe X or Xv
MDR phenotypes	No. (%), n = 32	No. (%), n = 16	No. (%), n = 34	No. (%), n = 1	No. (%), n = 2	No. (%), n = 1
AMP/SXT/CIP/MN/NA	0	3 (30C)^a	0	0	0	0
AMP/CTX/CPM/SXT/MN/NA	2	0	2	0	0	1
AMP/CTX/SXT/MN/NA/AZM	0	0	0	0	1 (19A)^a	0
AMP/CTX/ SXT/CIP/NA	0	0	0	1 (3C)^a	0	0
AMP/CTX/CPM/SXT/MN	1	0	3	0	0	0
AMP/CTX/SXT/MN	1	0	0	0	0	0

Multidrug-resistant (MDR) isolates are defined as those resistant to ≥ 3 classes among the third generation of cephalosporins, trimethoprim sulfamethoxazole, tetracycline, fluoroquinolones or macrolides
MDR, multidrug resistance; AMP, ampicillin; AZM, azithromycin; CPM, cefepime; CIP, ciprofloxacin; CTX, cefotaxime; MN, minocycline; NA, nalidixic acid; SXT, trimethoprim-sulfamethoxazole.
^a.S. flexneri isolates 19A, 3C, and 30C with related MDR patterns were used for gene expression analysis

ISSN: 1757-4749