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Table 2 The characteristics of the participants in RCTs

From: Adverse events of intestinal microbiota transplantation in randomized controlled trials: a systematic review and meta-analysis

Diseases

References

Sample size

Sex(M:F)

Mean age

SAEs (patients)

CAEs (patients)

CAEs (events)

IMT

CON

IMT

CON

IMT

CON

IMT

CON

IMT

CON

IMT

CON

rCDI

Cammarota et al. [33]

20

19

08:12

08:11

71

75

0

0

NR

NR

43

0

Kelly et al. [36]

22

24

04:18

05:19

48

55

0

0

NR

NR

NR

NR

Hota et al. [38]

16

12

05:11

04:08

75.7

69.6

0

0

NR

NR

88

95

Hvas et al. [43]

24

40

04:20

16:24

68

67.2

1

0

NR

NR

19

11

Total

82

95

0.9174

33:62

N/A

N/A

1

0

N/A

N/A

150

106

UC

Moayyedi et al. [34]

38

37

18:20

02:11

42.2

35.8

3

2

NR

NR

NR

NR

Rossen et al. [35]

23

25

11:12

11:14

40

41

0

0

18

16

21

24

Paramsothy et al. [39]

41

40

22:19

01:15

35.6

35.4

2

1

32

33

78

80

Costello et la. [41]

38

35

20:18

20:15

38.5

35

3

2

NR

NR

NR

NR

Sood et al. [44]

31

30

22:09

22:08

33

34.6

0

0

NR

NR

24

20

Total

171

167

93:78

104:63

N/A

N/A

8

5

50

49

123

124

Systemic sclerosis

Fretheim et al. [24]

5

4

00:05

00:04

58

66

0

1

5

4

35

13

Multidrug-resistant Enterobacteriaceae

Huttner ET AL. [42]

22

17

10:12

08:09

70

64

1

2

19

13

104

66

Obesity

Allegretti ET AL. [23]

11

11

01:10

01:10

44.5

43.2

0

0

NR

NR

26

25

Yu et al. [28]

12

12

04:08

03:09

42.5

38.5

0

0

NR

NR

34

25

Total

23

23

05:18

04:19

N/A

N/A

0

0

N/A

N/A

60

50

Alcohol Use Disorder

Bajaj et al. [37]

10

10

NR

NR

67.1

62.9

0

0

NR

NR

NR

NR

IBS

Halkjær et al. [12]

26

26

08:18

08:18

37.28

35.54

0

0

22

15

55

32

Johnsen et al. [13]

55

28

12:19

19:09

44

45

0

0

2

3

2

3

Aroniadis et al. [14]

48

48

06:18

06:18

37.31

37.31

0

0

NR

NR

23

24

El-Salhy et al. [46]

109

55

1.0181

08:47

39.3

41.2

0

0

NR

NR

90

12

Lahtinen et al. [47]

23

26

11:12

17:09

47.3

46.3

0

0

7

10

8

11

Total

251

183

108:153

82:101

N/A

N/A

0

0

31

28

178

82

Constipation

Tia et al. [40]

30

30

11:19

09:21

53.1

55.4

0

0

NR

NR

50

4

Total

603

529

248:345

240:279

N/A

N/A

10

8

105

94

700

445

  1. IMT intestinal microbiota transplantation, CON control, M male, F female, NR not reported, SAEs serious adverse events, CAEs common adverse events, N/A not applicable, rCDI recurrent Clostridioides difficile infection, UC Ulcerative colitis, IBS Inflammatory Bowel Disease