Fig. 2
From: Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease
Diarrhea onset, duration, and severity in Gn pigs. C. difficile infected pigs developed diarrhea within 48–72 h of inoculation. Student’s T-test, p < 0.0001 (A). All C. difficile inoculated pigs had diarrhea for some length of time while none of the PBS control pigs developed diarrhea at any point in the experiment. Student’s T-Test, p < 0.01 (B). At PID 5 and PID 10, C. difficile inoculated pigs had significantly higher cumulative diarrhea scores than PBS control pigs. Student’s T-test, p < 0.01 (C). The area under the curve (AUC) of diarrhea in C. difficile infected pigs was significantly higher than the PBS control pigs. Student’s T-test p < 0.001 (D)