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Table 2 Summary of clinical signs of Gn pigs during PID0–5 and PID 0–10

From: Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease

Treatment group n % affected (%) Diarrhea onset (mean days) Diarrhea duration (mean days PID 0–5) Mean cumulative diarrhea score PID 0–5 Mean daily weight gain from PID 0–5 Total weight gain from PID 0–5a Average weight at PID 5 (kg) n Mean days with diarrhea PID 0–10 Mean cumulative diarrhea score PID 0–10 Mean daily weight gain from PID 0–10 Total weight gain from PID 0–10 Average weight at PID 10 (kg)
C. difficile infected 5 100 2.6 (0.24)b 3.0 (0.55)Ac 9.4 (1.4)A 0.02 (0.10)A 0.1 1.6 2 8.5 (0.35)A 26 (0.71)A 0.09 (0.05)A 0.1 1.9
Mock-infected control 4 0 N/A 0 (0)B 0.75 (0.75)B 0.10 (0.05)A 0.5 2 2 0 (0)B 2.5 (1.77)B 0.01 (0.09)B 0.9 2.3
  1. aTotal weight gain is the sum of mean daily weight gain in each treatment group. All data for PID 0–5 included pigs euthanized on PID 5 and PID 10
  2. bNumber in parenthesis is standard error of the mean
  3. cDifferent capital letters (A, B) indicate significant difference among treatment groups for the same time point while shared letters indicate no significant difference. For diarrhea data, significance was determined with Student’s T test p < 0.05. For weight data, significance was determined with 2 Way ANOVA p < 0.05