Establishment of a gnotobiotic pig model of Clostridioides difficile infection and disease

Table 3 Summary of cytokine fold changes in serum and LIC

	Fold changes in cytokine concentration^a
	PID5		PID10
	Serum	LIC	Serum	LIC
GM-CSF	0.88	2.24	1.08	0.66
TNF alpha	1.16	21.09	1.29	13.88
IFN gamma	1.18	2.07	0.77	0.03
IL-1 alpha	1.08	63.29	11.16	3950.62
IL-1 beta	0.89	2.12	18.44	951.98
IL-1 ra	78.02	2.67	1130.69	293.23
IL-2	0.96	1.67	1.05	0.01
IL-4	0.96	5.07	0.87	0.33
IL-6	2.27	0.57	170.92	4.52
IL-8	2.69	10.03	0.89	589.29
IL-10	8.90	2.87	10.01	0.14
IL-12	0.66	8.89	1.16	67.15
IL-18	1.34	1.30	3.47	93.79

^aThe fold change between C. difficile and PBS control pigs was calculated by dividing the mean concentration of each cytokine in the C. difficile group by the mean concentration in the PBS control group for different sample types on different time points

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