The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease

Table 2 An overview of the metabolomic analysis outcome

Key metabolomics analysis results
Total metabolites identified	3146

Comparative analysis of differences between groups
Groups	Total differential metabolites	Significant difference metabolic pathways
IBD vs healthy controls	135	Vitamin digestion and absorption, primary bile acid biosynthesis, protein digestion and absorption, ABC transporters, basal cell carcinoma, glutathione metabolism, ferroptosis

AUC aggregate measure of performance of differential metabolites
Metabolite	AUC value
6,7,4′-trihydroxyisoflavone	0.92
Thyroxine 4′-o-.beta.-d-glucuronide	0.92
Trichostachine	0.91
[(2r,3 s,4 s,5r,6r)-3,4,5-trihydroxy-6-[2-(3-hydroxy-5-oxooxolan-3-yl)propoxy]oxan-2-yl]methyl (e)-3-(3,4-dihydroxyphenyl)prop-2-enoate	0.91
Normorphine	0.90
Salvinorin a	0.90
Esculetin	0.89
Mitraphylline	0.88
Indole-3-carboxaldehyde	0.88
Ginsenoside rh2	0.88
Arachidonoylserotonin	0.88
11-hydroxy-5z,8z,12e,14z,17z-eicosapentaenoic acid	0.88
10-deacetylbaccatin iii	0.88
9-cis-retinol	0.88
(5-benzoyloxy-3-chloro-4,6-dihydroxycyclohexen-1-yl)methyl benzoate	0.88
[(4e)-7-acetyloxy-6-hydroxy-2-methyl-10-oxo-2,3,6,7,8,9-hexahydrooxecin-3-yl] (e)-but-2-enoate	0.87
Dihydroberberine	0.87
N-nitrosopyrroolidine	0.87
Prothioconazole	0.87
Patchouli alcohol	0.87

ISSN: 1757-4749