Table 3 Dysregulated KEGG metabolic pathways and associated metabolites in IBD
From: The gut metagenomics and metabolomics signature in patients with inflammatory bowel disease
Pathway hierarchy | Map ID | Map name | Metabolite name | Up number | Down number |
|---|---|---|---|---|---|
Digestive system | hsa04977 | Vitamin digestion and absorption | Flavin mononucleotide (fmn), Pantothenate, Thiamine, ( +)-.alpha.-tocopherol, Cholesterol | 1 | 4 |
Digestive system | hsa04974 | Protein digestion and absorption | L-Valine, Isovaleric acid, Glutamic acid, DL-tyrosine, DL-Glutamic acid | 1 | 4 |
Lipid metabolism | hsa00120 | Primary bile acid biosynthesis | Cholic acid, 25-hydroxycholesterol, 7.alpha., 27-dihydroxycholesterol|Cholesterol | 1 | 3 |
Cell growth and death | hsa04216 | Ferroptosis | Glutamic acid, ( +)-.alpha.-tocopherol, DL-Glutamic acid, L-glutathione, reduced | 1 | 3 |
Membrane transport | hsa02010 | ABC transporters | L-Valine, Glycerol, Glutamic acid, Deoxyinosine|2′-deoxyinosine, Thiamine, DL-Glutamic acid, His-Lys, L-glutathione, reduced | 3 | 6 |
Metabolism of cofactors and vitamins | hsa00770 | Pantothenate and CoA biosynthesis | L-Valine, Uracil, Pantothenate | 1 | 2 |
Metabolism of cofactors and vitamins | hsa00730 | Thiamine metabolism | Thiamine monophosphate, DL-tyrosine, Thiamine | 1 | 2 |
Cancer: overview | hsa05230 | Central carbon metabolism in cancer | L-Valine, Glutamic acid, DL-tyrosine, DL-Glutamic acid | 1 | 3 |
Metabolism of other amino acids | hsa00480 | Glutathione metabolism | Glutamic acid, 5-L-Glutamyl-L-alanine, DL-Glutamic acid, L-glutathione, reduced | 1 | 3 |