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Table 1 Effect of diet including HFD used in this study on various haematological parameters

From: Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice

Parameters

Groups

Significance (p value)

CD

CD + A

HFD

HFD + A

CD vs CD + A

CD vs HFD

HFD vs HFD + A

Hb (g/dl)

15.46 ± 1.1

14.83 ± 0.6

14.26 ± 0.6

14.16 ± 0.5

NS

NS

NS

RBC (106 cells/ml)

9.40 ± 0.3

9.1 ± 0.4

8.77 ± 0.24

8.98 ± 0.4

NS

NS

NS

HCT (%)

58.23 ± 3.8

55.23 ± 2.8

52.56 ± 2.1

53.46 ± 2.2

NS

0.0226

NS

MCV (g)

61.9 ± 1.8

60.76 ± 0.3

60.0 ± 1.04

59.6 ± 0.7

NS

0.0218

NS

MCH (pg)

16.36 ± 0.5

16.26 ± 0.1

16.2 ± 0.3

15.7 ± 0.2

NS

NS

NS

MCHC(g/dl)

26.5 ± 0.2

26.83 ± 0.2

27.1 ± 0.6

26.6 ± 0.2

NS

NS

NS

RDW (%)

10.2 ± 0.34

9.72 ± 0.11

10.3 ± 0.57

9.7 ± 0.78

NS

NS

NS

WBC (106 cells/ml)

9.41 ± 1.1

10.52 ± 0.8

6.95 ± 1.3

6.92 ± 1.1

NS

0.0128

NS

Lymphocytes (106 cells/ml)

96.3 ± 0.7

93.6 ± 1.3

95.0 ± 2.7

93.6 ± 1.9

NS

NS

NS

Monocytes (%)

1.06 ± 0.1

2.4 ± 0.7

1.33 ± 0.7

2.8 ± 1.5

NS

NS

NS

Granulocytes (%)

0.26 ± 0.08

0.43 ± 0.08

0.27 ± 0.1

0.32 ± 0.1

NS

NS

NS

Thrombocytes (103/microL)

407.6 ± 76.2

400.3 ± 50.5

630.6 ± 55.08

459 ± 21.9

NS

 < 0.0001

 < 0.0001

  1. Values are expressed as the mean ± SD (n = 6). Data were analysed by One-way ANOVA followed by Bonferroni post-hoc test, p ≤ 0.05, NS = not significant, CD: Standard-chow diet for 3 weeks; CD + A: Standard-chow diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week; HFD: High-fat diet for 3 weeks (73% energy from fat); HFD + A: High-fat diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week
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Gut Pathogens

ISSN: 1757-4749