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Table 2 Effect of diet including HFD used in this study on various biochemical parameters

From: Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice

Parameters

Groups

Significance (p value)

CD

CD + A

HFD

HFD + A

CD vs CD + A

CD vs HFD

HFD vs HFD + A

Cholesterol (mg/dl)

71.49 ± 3.6

52.7 ± 0.3

127.39 ± 5.5

135.08 ± 3.1

 < 0.0001

 < 0.0001

NS

Triglycerides(mg/dl)

122.99 ± 7.5

95.44 ± 0.9

92.79 ± 7.1

102.41 ± 9.8

 < 0.0001

 < 0.0001

NS

ALT (IU)

56.80 ± 4.5

48.04 ± 0.5

53.12 ± 2.1

38.82 ± 6.3

NS

NS

0.0015

AST (IU)

74.47 ± 4.8

75.89 ± 1.6

83.08 ± 2.49

59.61 ± 6.07

NS

NS

 < 0.0001

Creatinine (mg/dl)

0.36 ± 0.06

0.37 ± 0.01

0.33 ± 0.005

0.30 ± 0.01

NS

NS

NS

Urea (mg/dl)

72.21 ± 4.5

66.15 ± 0.2

59.57 ± 1.9

57.20 ± 2.97

0.0029

 < 0.0001

NS

Glucose (mg/dl)

219.80 ± 13.08

231.54 ± 0.89

340.04 ± 14.7

290.77 ± 19.8

NS

 < 0.0001

 < 0.0001

  1. Values are expressed as the mean ± SD (n = 6). Data were analyzed by One-way ANOVA followed by Bonferroni post-hoc test, p ≤ 0.05, NS= not significant, CD: Standard-chow diet for 3 weeks; CD + A: Standard-chow diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week; HFD: High-fat diet for 3 weeks (73% energy from fat); HFD + A: High-fat diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week
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Gut Pathogens

ISSN: 1757-4749