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Table 3 Effect of diet on alpha diversity of gut microbiota in mice

From: Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice

Alpha diversity indices

Groups

Significance (p value)

CD

CD + A

HFD

HFD + A

CD vs CD + A

CD vs HFD

HFD vs HFD + A

OTUs

6468.7 ± 568.6

4871.6 ± 678.5

6543.4 ± 634.1

5104.7 ± 686.5

0.0013

NS

0.0053

Chao1

8682.7 ± 42.69

7152.3 ± 74.4

9354.4 ± 651.4

7500.5 ± 46.09

 < 0.0001

0.0229

0.0002

Shannon

6.99 ± 0.0132

5.63 ± 0.020

8.19 ± 0.055

6.39 ± 0.018

 < 0.0001

 < 0.0001

 < 0.0001

Simpson

0.933 ± 1.110

0.912 ± 0.00

0.979 ± 0.00

0.935 ± 0.00

NS

NS

NS

  1. Values are expressed as the mean ± SD (n = 6). Data were analyzed by One-way ANOVA followed by Bonferroni post-hoc test,  p≤ 0.05, NS =not significant, CD: Standard-chow diet for 3 weeks; CD + A: Standard-chow diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week; HFD: High-fat diet for 3 weeks (73% energy from fat); HFD + A: High-fat diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in  3rd week