Table 4 Effect of diet on the distribution of gut microbiota in mice at phylum level

From: Amoxicillin modulates gut microbiota to improve short-term high-fat diet induced pathophysiology in mice

Phylum	Relative abundance (%)				Significance (p value)
Phylum	CD	CD + A	HFD	HFD + A	CD vs CD + A	CD vs HFD	HFD vs HFD + A
Firmicutes	80.4 ± 0.396	1.80 ± 0.132	67.70 ± 0.467	73.70 ± 0.440	< 0.0001	< 0.0001	< 0.0001
Proteobacteria	7.50 ± 0.897	56.30 ± 0.496	13.80 ± 0.344	9.20 ± 0.289	< 0.0001	< 0.0001	< 0.0001
Bacteroidetes	5.20 ± 0.233	34.00 ± 0.473	1.40 ± 0.117	3.80 ± 0.191	< 0.0001	< 0.0001	< 0.0001
Actinobacteria	3.80 ± 0.191	3.60 ± 0.186	9.60 ± 0.294	9.10 ± 0.287	NS	< 0.0001	0.0143
Verrucomicrobia	0.20 ± 0.044	0.40 ± 0.063	0.30 ± 0.054	0.30 ± 0.054	< 0.0001	NS	NS
TM7	0.10 ± 0.031	0.10 ± 0.031	3.30 ± 0.178	0.10 ± 0.031	NS	< 0.0001	< 0.0001
Acidobacteria	0.30 ± 0.054	0.50 ± 0.070	0.60 ± 0.077	0.60 ± 0.077	0.0264	< 0.0001	NS
Cyanobacteria	0.50 ± 0.070	0.90 ± 0.094	0.30 ± 0.054	0.40 ± 0.063	< 0.0001	0.0002	0.0435
F/B ratio	15.46 ± 0.361	0.05 ± 0.022	48.35 ± 0.449	19.30 ± 0.394	< 0.0001	< 0.0001	< 0.0001

Values are expressed as the mean ± SD (n = 6). Data were analyzed by One-way ANOVA followed by Bonferroni post-hoc test, p ≤ 0.05, NS= not significant, CD: standard- chow diet for 3 weeks; CD + A: Standard- chow diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week; HFD: high-fat diet for 3 weeks (73% energy from fat); HFD + A: High-fat diet for 3 weeks and subjected to amoxicillin treatment (50 mg/kg body weight) in 3rd week

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ISSN: 1757-4749

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