Fig. 10

ROC curves illustrating the sensitivity and specificity of the factors identified through multivariate models. Factors identified for detecting a parent-reported wheeze were Firmicutes reads, Subdoligranulum reads and the number of courses of antibiotics given since 6 weeks of age and b parent-reported eczema were Firmicutes reads and gestation at birth. These factors were identified in the discovery set (37 matched premature and term infants), resulting in ROC curves shown in black. The validation set consisted of 30 term and 30 premature infants drawn randomly from a pool of 64 premature infants and 35 born at term 1000 times. The solid grey lines indicate the median curves from these 1000 iterations, and the dashed lines indicate the interquartile range