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Table 2 ADMET profile of lamivudine and chrysin estimated from SwissADME and admetSAR

From: Potential antiviral activities of chrysin against hepatitis B virus

Properties

Lamivudine

Chrysin

Absorption

BBB−

BBB+

 Blood–Brain barrier (BBB)

 GI–Absorption

High

High

 Caco-2 permeability

Caco-2−

Caco-2+

 Human intestinal absorption

HIA+

HIA+

Metabolism

No

Yes

 CYP1A2 inhibitor

 CYP2C19 inhibitor

No

No

 CYP2C9 inhibitor

No

No

 CYP2D6 inhibitor

No

Yes

 CYP3A4 inhibitor

No

Yes

 P-gp substrate(P-glycoprotein)

No

No

Toxicity

Non-toxic

Non-toxic

 Ames toxicity

 Carcinogenicity

Non-carcinogenic

Non-carcinogenic

Rule-of-five (RO5)

Not violated

Not violated

 Lipinski

 Ghose

Violated

Not violated

 Veber

Not violated

Not violated

 Egan

Not violated

Not violated

 Muegge

Not violated

Not violated