From: Potential antiviral activities of chrysin against hepatitis B virus
Properties | Lamivudine | Chrysin |
---|---|---|
Absorption | BBB− | BBB+ |
 Blood–Brain barrier (BBB) | ||
 GI–Absorption | High | High |
 Caco-2 permeability | Caco-2− | Caco-2+ |
 Human intestinal absorption | HIA+ | HIA+ |
Metabolism | No | Yes |
 CYP1A2 inhibitor | ||
 CYP2C19 inhibitor | No | No |
 CYP2C9 inhibitor | No | No |
 CYP2D6 inhibitor | No | Yes |
 CYP3A4 inhibitor | No | Yes |
 P-gp substrate(P-glycoprotein) | No | No |
Toxicity | Non-toxic | Non-toxic |
 Ames toxicity | ||
 Carcinogenicity | Non-carcinogenic | Non-carcinogenic |
Rule-of-five (RO5) | Not violated | Not violated |
 Lipinski | ||
 Ghose | Violated | Not violated |
 Veber | Not violated | Not violated |
 Egan | Not violated | Not violated |
 Muegge | Not violated | Not violated |