Articles

The novel norovirus genotype GII.17 is the predominant strain in diarrheal patients in Shanghai, China

In the winter of 2014–2015, a novel norovirus (NoV) strain (GII.17) was reported to be the major cause of gastroenteritis outbreaks in East Asia. To determine the time course of gastroenteritis infections asso...

Authors: Lifeng Pan, Caoyi Xue, Huiqin Fu, Dan Liu, Linying Zhu, Chang Cui, Weiping Zhu, Yifei Fu and Sun Qiao

Molecular epidemiology, virulence determinants and antimicrobial resistance of Campylobacter spreading in retail chicken meat in Central China

Campylobacter species are the major food-borne pathogens which could cause bacterial gastroenteritis in humans. Contaminated chicken products have been recognized as the primary vehicl...

Authors: Tengfei Zhang, Qingping Luo, Yiluo Chen, Tingting Li, Guoyuan Wen, Rongrong Zhang, Ling Luo, Qin Lu, Diyun Ai, Hongcai Wang and Huabin Shao

Whole genome sequencing uncovers a novel IND-16 metallo-β-lactamase from an extensively drug-resistant Chryseobacterium indologenes strain J31

Chryseobacterium indologenes is an emerging opportunistic pathogen in hospital-acquired infection, which is intrinsically resistant to most antimicrobial agents against gram-negative b...

Authors: Tingting Wang, Xiawei Jiang, Chunyan Feng, Ang Li, Huihui Dong, Shaoqiang Wu and Beiwen Zheng

The emergence of Klebsiella pneumoniae liver abscess in non-diabetic patients and the distribution of capsular types

Klebsiella pneumoniae is the most common pathogen of community-acquired pyogenic liver abscess in East Asia. Diabetes mellitus (DM) is a well-established risk factor for K. pneumoniae ...

Authors: Chien Chuang, Wen-Chien Fan, Yi-Tsung Lin and Fu-Der Wang

A single capsule formulation of RHB-104 demonstrates higher anti-microbial growth potency for effective treatment of Crohn’s disease associated with Mycobacterium avium subspecies paratuberculosis

Most recently we reported that RHB‑104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease (CD)-associated with Mycobacterium avium subspecies paratu...

Authors: Ahmad Qasem, Mitra Safavikhasraghi and Saleh A. Naser

Multilocus sequence typing of Campylobacter concisus from Danish diarrheic patients

The emerging enteric pathogen Campylobacter concisus is associated with prolonged diarrhea and inflammatory bowel disease. Previous studies have shown that C. concisus strains are very genetically diverse. Nevert...

Authors: Hans Linde Nielsen, Henrik Nielsen and Mia Torpdahl

Zonula occludens toxins and their prophages in Campylobacter species

We previously showed that zonula occludens toxin (Zot) encoded by Campylobacter concisus zot ^808T gene has the potential to initiate inflammatory bowel disease. This Zot protein caused ...

Authors: Fang Liu, Hoyul Lee, Ruiting Lan and Li Zhang

Gut microbiome alterations in patients with stage 4 hepatitis C

Hepatitis C virus (HCV) causes debilitating liver diseases, which may progress to cirrhosis and cancer, and claims 500,000 annual lives worldwide. While HCV epidemiology, pathophysiology, and therapy are being...

Authors: AbdelRahman Mahmoud Aly, AbdelReheem Adel, Ahmed Osama El-Gendy, Tamer M. Essam and Ramy K. Aziz

Does antibiotic resistance impair plasma susceptibility of multi-drug resistant clinical isolates of enterococci in vitro?

Cold atmospheric plasma could constitute an alternative against multi-drug resistant pathogens. Susceptibility of enterococci to cold atmospheric plasma was investigated in vitro.

Authors: Matthias Napp, Sebastian von Podewils, Ingo Klare, Hermann Haase, Richard Kasch, Denis Gümbel, Axel Ekkernkamp, Michael Jünger and Georg Daeschlein

Antimicrobial resistance and integron gene cassette arrays in commensal Escherichia coli from human and animal sources in IRI

The human and animal intestinal tract harbors a complex community of microbes which enables bacteria to inherit antibiotic resistance genes. The aims of this study were to investigate clonality, antimicrobial ...

Authors: Roohollah Kheiri and Leili Akhtari

Antimicrobial resistance of Campylobacter isolates from small scale and backyard chicken in Kenya

Thermophilic Campylobacter species are a major cause of bacterial foodborne diarrhoea in humans worldwide. Poultry and their products are the predominant source for human campylobacteriosis. Resistance of Campylo...

Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, John Njeru, Joyce Mwituria, Hosny El-Adawy, Herbert Tomaso, Heinrich Neubauer and Hafez M. Hafez

Erratum to: Genome sequencing, annotation and comparative genomic analysis of Shigella dysenteriae strain SD1D

Authors: Gurwinder Kaur, Sathyaseelan Sathyabama, Amit Arora, Sheenam Verma, Nida Mubin, Javed N. Agrewala and Shanmugam Mayilraj

Genome sequence of OXA-23 producing Acinetobacter baumannii IHIT7853, a carbapenem-resistant strain from a cat belonging to international clone IC1

Multidrug resistance in Acinetobacter baumannii has dramatically increased in recent years worldwide. Thus, last-line antibiotics like carbapenems are increasingly being used which in turn further augments select...

Authors: Christa Ewers, Peter Klotz, Sandra Scheufen, Ursula Leidner, Stephan Göttig and Torsten Semmler

Dysfunctional gut microbiota and relative co-abundance network in infantile eczema

Infantile eczema is an immunological disease that is characterized by itchy and dry skin. Recent studies have suggested that gut microbiota (GM) plays a role in the development and progression of eczema. To fu...

Authors: Heping Wang, Yinhu Li, Xin Feng, Yufeng Li, Wenjian Wang, Chuangzhao Qiu, Jianqiang Xu, Zhenyu Yang, Zhichuan Li, Qian Zhou, Kaihu Yao, Hongmei Wang, Yuzheng Li, Dongfang Li, Wenkui Dai and Yuejie Zheng

Erratum to: The Salmonella pathogenicity island 13 contributes to pathogenesis in streptomycin pre-treated mice but not in day-old chickens

Authors: Jacob R. Elder, Kim Lam Chiok, Narayan C. Paul, Gary Haldorson, Jean Guard and Devendra H. Shah

Comparative genomic analysis of Klebsiella pneumoniae subsp. pneumoniae KP617 and PittNDM01, NUHL24835, and ATCC BAA-2146 reveals unique evolutionary history of this strain

Klebsiella pneumoniae subsp. pneumoniae KP617 is a pathogenic strain that coproduces OXA-232 and NDM-1 carbapenemases. We sequenced the genome of KP617, which was isolated from the wou...

Authors: Taesoo Kwon, Young-Hee Jung, Sanghyun Lee, Mi-ran Yun, Won Kim and Dae-Won Kim

The IL-23/IL-22/IL-18 axis in murine Campylobacter jejuni infection

Human Campylobacter jejuni infections are worldwide on the rise. Information about the distinct molecular mechanisms underlying campylobacteriosis, however, are scarce. In the present study we investigated whethe...

Authors: Markus M. Heimesaat, Ursula Grundmann, Marie E. Alutis, André Fischer, Ulf B. Göbel and Stefan Bereswill

Bacteriophage infections of microbiota can lead to leaky gut in an experimental rodent model

Increased intestinal permeability and translocation of gut microbiota from the intestinal lumen to the systemic circulation predispose patients to various diseases and may be one of the main triggers thereof. ...

Authors: George Tetz and Victor Tetz

Complete genome sequence of Vibrio vulnificus FORC_017 isolated from a patient with a hemorrhagic rash after consuming raw dotted gizzard shad

Vibrio vulnificus, a resident in the human gut, is frequently found in seafood, causing food-borne illnesses including gastroenteritis and severe septicemia. While V. vulnificus has be...

Authors: Han Young Chung, You-Tae Kim, Suyeon Kim, Eun Jung Na, Hye-Jin Ku, Keun Hwa Lee, Sang Taek Heo, Sangryeol Ryu, Heebal Kim, Sang Ho Choi and Ju-Hoon Lee

RHB-104 triple antibiotics combination in culture is bactericidal and should be effective for treatment of Crohn’s disease associated with Mycobacterium paratuberculosis

Mycobacterium avium subspecies paratuberculosis (MAP) has been implicated as an etiological agent of Crohn’s disease (CD), a debilitating chronic inflammatory bowel disease. Clarithrom...

Authors: Karel P. Alcedo, Saisathya Thanigachalam and Saleh A. Naser

Prevalence and antibiotic resistance of bacterial pathogens isolated from childhood diarrhea in Beijing, China (2010–2014)

Diarrhea is one of the main causes of morbidity and mortality among children less than 5 years of age worldwide, and its causes vary by region. This study aimed to determine the etiologic spectrum, prevalent c...

Authors: Mei Qu, Bing Lv, Xin Zhang, Hanqiu Yan, Ying Huang, Haikun Qian, Bo Pang, Lei Jia, Biao Kan and Quanyi Wang

Duck gut viral metagenome analysis captures snapshot of viral diversity

Ducks (Anas platyrhynchos) an economically important waterfowl for meat, eggs and feathers; is also a natural reservoir for influenza A viruses. The emergence of novel viruses is attributed to the status of co-ex...

Authors: Mohammed Fawaz, Periyasamy Vijayakumar, Anamika Mishra, Pradeep N. Gandhale, Rupam Dutta, Nitin M. Kamble, Shashi B. Sudhakar, Parimal Roychoudhary, Himanshu Kumar, Diwakar D. Kulkarni and Ashwin Ashok Raut

Calcium binding protects E-cadherin from cleavage by Helicobacter pylori HtrA

The cell adhesion and tumor suppressor protein E-cadherin is an important factor in the establishment and maintenance of epithelial integrity. E-cadherin is a single transmembrane protein, which consists of an...

Authors: Thomas P. Schmidt, Camilla Goetz, Markus Huemer, Gisbert Schneider and Silja Wessler

Prevalence, genotyping and risk factors of thermophilic Campylobacter spreading in organic turkey farms in Germany

The need for organic food of animal origin has increased rapidly in recent years. However, effects of organic animal husbandry on food safety have not been rigorously tested especially in meat turkey flocks. T...

Authors: Marwa Fawzy El Metwaly Ahmed, Hosny El-Adawy, Helmut Hotzel, Herbert Tomaso, Heinrich Neubauer, Nicole Kemper, Joerg Hartung and Hafez Mohamed Hafez

The efficacy of thuricin CD, tigecycline, vancomycin, teicoplanin, rifampicin and nitazoxanide, independently and in paired combinations against Clostridium difficile biofilms and planktonic cells

Thuricin CD is a two-component antimicrobial, belonging to the recently designated sactibiotic subclass of bacteriocins. The aim of this study was to investigate the effects of thuricin CD, as well as the anti...

Authors: Harsh Mathur, Mary C. Rea, Paul D. Cotter, Colin Hill and R. Paul Ross

Optimized cultivation of Campylobacter concisus from gut mucosal biopsies in inflammatory bowel disease

Campylobacter concisus is a commensal of the human oral flora that has been linked to prolonged diarrhea and inflammatory bowel disease (IBD). It has been detected more often from inte...

Authors: Karina Frahm Kirk, Hans Linde Nielsen, Ole Thorlacius-Ussing and Henrik Nielsen

Serotype epidemiology and multidrug resistance patterns of Salmonella enterica infecting humans in Italy

Salmonella enterica is the zoonotic agent most frequently responsible for foodborne infections in humans worldwide. In this work the presence of S. enterica was investigated in 734 uni...

Authors: Ilaria Frasson, Sabrina Bettanello, Ettore De Canale, Sara N. Richter and Giorgio Palù

Analysis of cultivable microbiota and diet intake pattern of the long-lived naked mole-rat

A variety of microbial communities exist throughout the human and animal body. Genetics, environmental factors and long-term dietary habit contribute to shaping the composition of the gut microbiota. For this ...

Authors: Tewodros Debebe, Susanne Holtze, Michaela Morhart, Thomas Bernd Hildebrandt, Steffen Rodewald, Klaus Huse, Matthias Platzer, Dereje Wyohannes, Salomon Yirga, Alemayehu Lemma, Rene Thieme, Brigitte König and Gerd Birkenmeier

Inherent bacterial DNA contamination of extraction and sequencing reagents may affect interpretation of microbiota in low bacterial biomass samples

The advent and use of highly sensitive molecular biology techniques to explore the microbiota and microbiome in environmental and tissue samples have detected the presence of contaminating microbial DNA within...

Authors: Angela Glassing, Scot E. Dowd, Susan Galandiuk, Brian Davis and Rodrick J. Chiodini

Host, pathogen and environment: a bacterial gbpA gene expression study in response to magnesium environment and presence of prawn carapace and commercial chitin

Vibrio parahaemolyticus is a Gram-negative halophilic bacterium which is found largely in estuarine and coastal waters. The bacteria has been a main focus in gastro-intestinal infectio...

Authors: Suma Tiruvayipati and Subha Bhassu

Examination of the effects of Campylobacter concisus zonula occludens toxin on intestinal epithelial cells and macrophages

Campylobacter concisus is a Gram-negative bacterium that is associated with inflammatory bowel disease (IBD). Some C. concisus strains carry zonula occludens toxin (zot) gene which has...

Authors: Vikneswari Mahendran, Fang Liu, Stephen M. Riordan, Michael C. Grimm, Mark M. Tanaka and Li Zhang

Genotyping and antibiotic resistance of thermophilic Campylobacter isolated from chicken and pig meat in Vietnam

Campylobacter species are recognized as the most common cause of foodborne bacterial gastroenteritis in humans. In this study nine Campylobacter strains isolated from chicken meat and ...

Authors: Tuan Ngoc Minh Nguyen, Helmut Hotzel, Hosny El-Adawy, Hanh Thi Tran, Minh Thi Hong Le, Herbert Tomaso, Heinrich Neubauer and Hafez Mohamed Hafez

Global investigation of composition and interaction networks in gut microbiomes of individuals belonging to diverse geographies and age-groups

Factors like ethnicity, diet and age of an individual have been hypothesized to play a role in determining the makeup of gut microbiome. In order to investigate the gut microbiome structure as well as the inte...

Authors: Deepak Yadav, Tarini Shankar Ghosh and Sharmila S. Mande

The Salmonella pathogenicity island 13 contributes to pathogenesis in streptomycin pre-treated mice but not in day-old chickens

Salmonella enterica serovar Enteritidis (S. Enteritidis) is a human and animal pathogen that causes gastroenteritis characterized by inflammatory diarrhea and occasionally an invasive ...

Authors: Jacob R. Elder, Kim Lam Chiok, Narayan C. Paul, Gary Haldorson, Jean Guard and Devendra H. Shah

Host, pathogen and the environment: the case of Macrobrachium rosenbergii, Vibrio parahaemolyticus and magnesium

Macrobrachium rosenbergii is well-known as the giant freshwater prawn, and is a commercially significant source of seafood. Its production can be affected by various bacterial contaminati...

Authors: Suma Tiruvayipati and Subha Bhassu

Draft genome sequence of non-shiga toxin-producing Escherichia coli O157 NCCP15738

The non-shiga toxin-producing Escherichia coli (non-STEC) O157 is a pathogenic strain that cause diarrhea but does not cause hemolytic-uremic syndrome, or hemorrhagic colitis. Here, we present the 5-Mb draft geno...

Authors: Taesoo Kwon, Jung-Beom Kim, Young-Seok Bak, Young-Bin Yu, Ki Sung Kwon, Won Kim and Seung-Hak Cho

Genotyping of Salmonella Typhi using 8-loci multi locus VNTR analysis

Typhoid fever has caused severe epidemics in many Asian and African countries. The early detection of outbreaks and their sources may promote the prevention and control of typhoid fever, for which effective an...

Authors: Hongxia Wang, Baowei Diao, Zhigang Cui, Meiying Yan and Biao Kan

Complete genome sequence of Peptoclostridium difficile strain Z31

Peptoclostridium (Clostridium) difficile is a spore-forming bacterium responsible for nosocomial infections in humans. It is recognized as an important agent of diarrhea and colitis in...

Authors: Felipe L. Pereira, Carlos A. Oliveira Júnior, Rodrigo O. S. Silva, Fernanda A. Dorella, Alex F. Carvalho, Gabriel M. F. Almeida, Carlos A. G. Leal, Francisco C. F. Lobato and Henrique C. P. Figueiredo

Helicobacter pylori plasticity region genes are associated with the gastroduodenal diseases manifestation in India

Almost all Helicobacter pylori infected person develop gastritis and severe gastritis is supposed to be the denominator of peptic ulcer diseases, which may lead to gastric cancer. However, it is still an enigma w...

Authors: Mou Ganguly, Sagartirtha Sarkar, Prachetash Ghosh, Avijit Sarkar, Jawed Alam, Bipul Chandra Karmakar, Ronita De, Dhira Rani Saha and Asish K. Mukhopadhyay

The isolation and molecular characterization of Mycobacterium avium subsp. paratuberculosis in Shandong province, China

Mycobacterium avium subspecies paratuberculosis (Map) causes Johne’s disease in domestic and wild ruminants. It has been a debate that whether Map can cause Crohn’s disease in human. T...

Authors: Ruichao Yue, Chunfa Liu, Paul Barrow, Fei Liu, Yongyong Cui, Lifeng Yang, Deming Zhao and Xiangmei Zhou

Systematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA

It has been suggested that the prevalence of Helicobacter pylori infection has stabilized in the USA and is decreasing in China. We conducted a systematic literature analysis to test this hypothesis. PubMed and E...

Authors: Peter Nagy, Saga Johansson and Michael Molloy-Bland

Oxidative stress due to Mycobacterium avium subspecies paratuberculosis (MAP) infection upregulates selenium-dependent GPx activity

This study was designed to determine the relationship between Mycobacterium avium subspecies paratuberculosis (MAP) infection and selenium-dependent glutathione peroxidase (GPx) activity, in the blood of humans a...

Authors: Ahmad Qasem, Ahmad Abdel-Aty, Huda Abu-Suwa and Saleh A. Naser

Genome sequence of Escherichia coli NCCP15653, a group D strain isolated from a diarrhea patient

Pathogenic strains in Escherichia coli can be divided into several pathotypes according to their virulence features. Among them, uropathogenic E. coli causes most of the urinary tract infections and has a genotyp...

Authors: Min-Jung Kwak, Myung-Soo Kim, Soon-Kyeong Kwon, Seung-Hak Cho and Jihyun F. Kim

Genomic characterization and assessment of the virulence and antibiotic resistance of the novel species Paenibacillus sp. strain VT-400, a potentially pathogenic bacterium in the oral cavity of patients with hematological malignancies

Paenibacillus sp. strain VT-400, a novel spore-forming bacterium, was isolated from patients with hematological malignancies.

Authors: George Tetz, Victor Tetz and Maria Vecherkovskaya

De Novo sphingolipid synthesis is essential for Salmonella-induced autophagy and human beta-defensin 2 expression in intestinal epithelial cells

Sphingolipids are important for innate immune response to eliminate infected pathogens and involved in autophagy. On the other hand, nucleotide-binding oligomerization domain-containing protein 2 (NOD2) served...

Authors: Fu-Chen Huang

Surface antigens contribute differently to the pathophysiological features in serotype K1 and K2 Klebsiella pneumoniae strains isolated from liver abscesses

The virulence role of surface antigens in a single serotype of Klebsiella pneumoniae strain have been studied, but little is known about whether their contribution will vary with serotype.

Authors: Kuo-Ming Yeh, Sheng-Kung Chiu, Chii-Lan Lin, Li-Yueh Huang, Yu-Kuo Tsai, Jen-Chang Chang, Jung-Chung Lin, Feng-Yee Chang and Leung-Kei Siu

Whole genome sequencing of “Faecalibaculum rodentium” ALO17, isolated from C57BL/6J laboratory mouse feces

Intestinal microorganisms affect host physiology, including ageing. Given the difficulty in controlling for human studies of the gut microbiome, mouse models provide an alternative avenue to study such relatio...

Authors: Sooyeon Lim, Dong-Ho Chang, Sharon Ahn and Byoung-Chan Kim

Increased dosage of infliximab is a potential cause of Pneumocystis carinii pneumonia

Pneumocystis carinii pneumonia occasionally appears in immunodeficient patients. While several reports have shown that Pneumocystis carinii pneumonia occurred in the early phase of sta...

Authors: Takuya Iwama, Aki Sakatani, Mikihiro Fujiya, Kazuyuki Tanaka, Shugo Fujibayashi, Yoshiki Nomura, Nobuhiro Ueno, Shin Kashima, Takuma Gotoh, Junpei Sasajima, Kentaro Moriichi and Katsuya Ikuta

Helicobacter pylori strains harboring babA2 from Indian sub population are associated with increased virulence in ex vivo study

The babA2 gene along with the cagA and vacA of Helicobacter pylori has been considered as a risk factor for the disease outcome in certain populations. This study was aimed to understand the role of babA2 of H. p...

Authors: Prachetash Ghosh, Avijit Sarkar, Mou Ganguly, Raghwan, Jawed Alam, Ronita De and Asish K. Mukhopadhyay

Lactobacilli with probiotic potential in the prairie vole (Microtus ochrogaster)

Recent research suggests integration of the intestinal microbiota in gut-brain communication which could lead to new approaches to treat neurological disorders. The highly social prairie voles are an excellen...

Authors: Senait Assefa, Kathleen Ahles, Simone Bigelow, J. Thomas Curtis and Gerwald A. Köhler