Table 2 Candidate genes involved in M. rosenbergii immune response against V. parahaemolyticus

Antimicrobial

Unigene4120_all

Anti-lipopolysaccharide factor

Macrobrachium rosenbergii

4.13

Unigene23546_all

Anti-lipopolysaccharide factor 2

Macrobrachium rosenbergii

2.84

CL1276.Contig1_all

Anti-lipopolysaccharide factor 3

Macrobrachium rosenbergii

2.15

Unigene37309_all

Crustin

Macrobrachium rosenbergii

5.13

Unigene26338_all

Lysozyme

Portunus trituberculatus

1.92

Unigene13073_all

NF-kappa B inhibitor alpha

Macrobrachium rosenbergii

3.11

Blood clotting system

Unigene13048_all

Clottable protein

Marsupenaeus japonicus

1.42

Unigene34308_all

Transglutaminase

Macrobrachium rosenbergii

11.34

Unigene36567_all

Proclotting enzyme

Harpegnathos saltator

11.22

Unigene41253_all

Coagulation factor XII

Hageman factor

10.61

PRPs

Unigene10978_all

Lectin 1

Macrobrachium rosenbergii

4.4

CL4516.Contig1_all

Lectin 2

Macrobrachium rosenbergii

1.05

Unigene7825_all

Lectin 3

Macrobrachium rosenbergii

2.54

CL3039.Contig4_all

Lectin 4

Macrobrachium rosenbergii

4.55

Unigene9635_all

C-type lectin

Penaeus monodon

1.14

CL1600.Contig1_all

C-type lectin-2

Litopenaeus vannamei

1.69

CL5230.Contig3_all

C-type lectin 5

Fenneropenaeus chinensis

2

Unigene1391_all

Hemolectin

Papilio xuthus

5.81

Unigene25701_all

M-type lectin

Marsupenaeus japonicus

1.69

Unigene23215_all

Perlucin-like protein

Mytilus galloprovincialis

−1.92

CL1075.Contig4_all

Tachylectin

Macrobrachium rosenbergii

−1.71

Unigene28944_all

Ficolin

Branchiostoma floridae

1.31

Unigene19793_all

Lectin B isoform 2

Marsupenaeus japonicus

3.55

Unigene37041_all

Mannose-binding protein

Procambarus clarkii

11.69

CL1124.Contig1_all

Glucan pattern-recognition lipoprotein

Fenneropenaeus chinensis

1.12

Unigene23671_all

lipopolysaccharide and beta-1,3-glucan binding protein

Macrobrachium rosenbergii

1.71

Proteinases and proteinases inhibitors

Unigene1509_all

Cathepsin B

Pandalus borealis

1.87

Unigene22859_all

Cathepsin C

Fenneropenaeus chinensis

2.33

CL1587.Contig2_all

Cathepsin D

Penaeus monodon

−1.56

Unigene26111_all

Cathepsin L

Pandalus borealis

1.41

CL5824.Contig1_all

Serpin serine protease inhibitor

Fenneropenaeus chinensis

12.24

CL6038.Contig1_all

26S protease regulatory

Nasonia vitripennis

1.44

Unigene12869_all

Alpha-2-macroglobulin

Macrobrachium rosenbergii

5.09

CL2365.Contig1_all

Caspase

Marsupenaeus japonicus

1.04

Unigene13293_all

Astacin

Strongylocentrotus purpuratus

1.64

Unigene13633_all

Serine protease

Fenneropenaeus chinensis

3.08

Unigene17259_all

Caspase 8

Ictalurus punctatus

2.41

CL2565.Contig1_all

Serine proteinase inhibitor 6

Penaeus monodon

4.51

CL1118.Contig1_all

Serpin B

Marsupenaeus japonicus

7.02

Unigene26757_all

Hemocyte kazal-type proteinase inhibitor

Penaeus monodon

3.87

CL1127.Contig2_all

Kazal-type serine proteinase inhibitor 4

Procambarus clarkii

−6.01

CL5487.Contig2_all

Aminopeptidase N

Camponotus floridanus

1.4

Unigene5621_all

Masquerade-like serine proteinase-like protein 2

Penaeus monodon

5.39

Unigene21512_all

Serine proteinase inhibitor

Macrobrachium rosenbergii

6.91

Unigene28987_all

CUB-serine protease

Panulirus argus

2.92

Heat shock proteins

Unigene3736_all

Heat shock protein 21

Macrobrachium rosenbergii

4.61

Unigene23034_all

Heat shock protein 40

Frankliniella occidentalis

1.8

Unigene14757_all

Heat shock protein 70

Portunus trituberculatus

2.26

CL4309.Contig3_all

Heat shock protein 90

Scylla paramamosain

1.93

Unigene16858_all

Small heat shock protein

Fenneropenaeus chinensis

2.41

Oxidative stress

CL353.Contig2_all

Glutathione S transferase

Procambarus clarkii

1.01

Unigene19405_all

Cu/Zn superoxide dismutase

Bombyx mori

1.61

CL5590.Contig3_all

Glutamine synthetase

Panulirus argus

−3.03

CL559.Contig1_all

Farnesoic acid O-methyltransferase

Nilaparvata lugens

1.81

CL2477.Contig1

Catalase

Litopenaeus vannamei

1.6

CL2787.Contig2

Thioredoxin reductase

Branchiostoma floridae

1.09

Cytoskeletal

Unigene10471

Chitinase

Trichomonas vaginalis

6.16

CL6026.Contig5_all

Actin

Marsupenaeus japonicus

2.92

Unigene13021_all

Calponin

Chironomus riparius

2.32

CL5710.Contig1_all

Profilin

Fenneropenaeus chinensis

1.45

CL461.Contig8_all

Tubulin

Homarus americanus

1.39

Unigene19173_all

Beta-integrin

Fenneropenaeus chinensis

2.78

CL2046.Contig1_all

Integrin

Litopenaeus vannamei

3.03

Signal transduction

Toll pathway

CL1915.Contig5_all

Toll interacting protein

Marsupenaeus japonicus

1.73

CL5402.Contig1_all

Toll receptor 2

Marsupenaeus japonicus

−2.46

Unigene25507_all

Toll-like receptor 3

Daphnia pulex

2.59

CL2421.Contig1_all

Toll-like receptor 8

Ixodes scapulari

1.48

Unigene25799_all

Myd88 protein

Artemia sinica

3.25

Unigene9776_all

Caspase

Fenneropenaeus merguiensis

3.08

Unigene14481_all

Dorsal

Fenneropenaeus chinensis

3.19

Wnt signaling pathway

Unigene36938_all

Lipoprotein receptor

Callinectes sapidus

10.94

Unigene15960_all

Prickle

Saccoglossus kowalevskii

1.71

Unigene15970_all

Low-density lipoprotein receptor-related protein 6

Daphnia pulex

2.05

Unigene12737_all

Glypican 4

Daphnia pulex

1.14

Unigene25938_all

Secreted frizzled-related protein 5

Daphnia pulex

1.82

MAPK signaling pathway

Unigene26817_all

Mitogen-activated protein kinase kinase kinase 1

Oryctolagus cuniculus

2.79

Unigene110_all

Mitogen-activated protein kinase 8 interacting protein 3

Bombus terrestris

2.94

CL726.Contig3_all

Mitogen-activated protein kinase kinase kinase kinase 4

Bombus terrestris

1.65

CL3174.Contig1_all

Mitogen-activated protein kinase kinase kinase 7

Danaus plexippus

1.41

Unigene29569_all

Mitogen-activated protein kinase kinase kinase 13

Bombus terrestris

4.03

CL4432.Contig2_all

Max protein

Daphnia pulex

−3.11

Unigene14757_all

Heat shock protein 70

Portunus trituberculatus

2.26

Unigene3873_all

Protein phosphatase 5

Bombus terrestris

1.21

Unigene102_all

Map kinase-interacting serine/threonine

Scylla paramamosain

2.48

Unigene11596_all

Raf homolog serine/threonine-protein kinase phl-like

Nasonia vitripennis

2.41

JAK/STAT pathway

Unigene25562_all

STAT long form

Penaeus monodon

2.84

Unigene25762_all

Signal transducing adaptor molecule

Megachile rotundata

1.98

Unigene16474_all

Tumor susceptibility gene 101 protein

Harpegnathos saltator

2.46

CL1133.Contig6_all

Domeless

Tribolium castaneum

2.94

Unigene28876_all

Thyroid peroxidase

Pediculus humanus corporis

3.66

Other signal transduction genes

CL1409.Contig1_all

Innexin 3

Cancer borealis

10.29

Unigene30035_all

cAMP-dependent protein kinase type II regulatory subunit

Camponotus floridanus

1.05

CL3406.Contig2_all

Casein kinase II subunit alpha

Danaus plexippus

1.75

CL4247.Contig1_all

Rab-protein 14

Tribolium castaneum

1.85

Unigene37520_all

Afadin

Pediculus humanus corporis

2.89

Unigene34256_all

TBC1 domain family member 10B

Crassostrea gigas

11.52

Unigene33128_all

REM2- and Rab-like small GTPase 1-like

Cavia porcellus

3.21

ProPO system

Unigene12734_all

Prophenoloxidase

Macrobrachium rosenbergii

3.15

Unigene7353_all

Prophenoloxidase activating factor

Fenneropenaeus chinensis

3.79

Unigene18337_all

Prophenoloxide activating enzyme III

Macrobrachium rosenbergii

4.99

Cell death

Unigene2555_all

Beclin 1

Megachile rotundata

11.89

CL1843.Contig2_all

ALG-2 interacting protein x Penaeus monodon

Penaeus monodon

3.2

Unigene14045_all

Program cell death 5-like

Penaeus monodon

1.61

CL2477.Contig1_all

Catalase

Litopenaeus vannamei

1.6

Unigene3163_all

inhibitor of apoptosis protein

Litopenaeus vannamei

1.02

Unigene9776_all

Caspase

Fenneropenaeus merguiensis

3.08

Unigene36052_all

DNA fragmentation factor subunit beta

Danio rerio

3.26

Other immune genes

CL4920.Contig1_all

Calmodulin

Procambarus clarkii

1.92

CL1939.Contig4_all

Ferritin

Litopenaeus vannamei

−2.87

CL4071.Contig2_all

Peritrophin

Macrobrachium nipponense

−2.18

Unigene10835_all

Selenoprotein W

Cricetulus griseus

−1.98

Unigene26739_all

Metallothionein I

Macrobrachium rosenbergii

−2.75

Unigene29279_all

Selenoprotein L

Ciona intestinalis

1.06

CL6324.Contig2_all

Arginine kinase 1

Macrobrachium rosenbergii

4.67

CL5294.Contig2_all

Hemocyanin

Macrobrachium nipponense

1.21

Unigene26326_all

Tetraspanin-like protein CD9

Fenneropenaeus chinensis

1.02

CL4316.Contig1_all

Crustacyanin-like lipocalin

Macrobrachium rosenbergii

−4.12

CL6297.Contig2_all

E cadherin

Tenebrio molitor

3.19

CL2339.Contig2_all

Adenosine deaminase

Caligus rogercresseyi

−1.35

CL3196.Contig2_all

Calnexin

Penaeus monodon

1.57

CL2701.Contig1_all

Ubiquitin-conjugating enzyme

Macrobrachium nipponense

1.33