(%) Sensitivity (95% CI) | (%) Specificity (95% CI) | Positive predictive value (%) (95% CI) | Negative predictive value (%) (95% CI) | |
---|---|---|---|---|
DiaSorin algorithm = CLIA GDH + CLIA toxins A/B | 86.7 (68.4–95.6) | 99.1 (97.7–99.8) | 86.7 (68.3–95.6) | 98.1 (97.5–99.7) |
Meridian algorithm = EIA GDH + NAAT for toxin gene | 90.0 (72.3–97.8) | 98.9 (97.4–99.5) | 84.4 (66.5–94.1) | 99.3 (97.8–99.8) |
2-Step Alere algorithm = EIA GDH + EIA toxins A/B | 50.0 (31.7–68.3) | 99.5 (98.1–99.9) | 88.2 (62.2–97.9) | 96.7 (94.5–98.1) |
3-Step Alere algorithm = EIA GDH + EIA toxins A/B + toxigenic culture | 60.0 (40.7–76.7) | 99.5 (98.1–99.9) | 90.0 (66.8–98.2) | 97.3 (95.2–98.5) |