A case–control study of the association between the gut microbiota and colorectal cancer: exploring the roles of diet, stress, and race

Table 2 Associations of alpha diversity estimates with colorectal cancer among black and white women (N = 33; 11 colorectal cancer cases, and 22 cancer-free controls)

Alpha diversity metric (range)^a	Colorectal cancer	Cancer-free	Unadjusted		Adjusted
Alpha diversity metric (range)^a	n (%)	n (%)	OR (95% CI)	P-value	OR (95% CI)^b	P-value
	11	22
Observed
Continuous [mean (SD)]	[338.36 (56.55)]	[311.18(61.50)]	1.00 (1.00, 1.02)	0.23	1.01 (1.00, 1.03)	0.21
Quantile 1 (185–310)	3 (27.3)	11 (50.0)	1.00 (referent)	0.22	1.00 (referent)	0.14
Quantile 2 (312–428)	8 (72.7)	11 (50.0)	2.70 (0.59, 14.74)		4.48 (0.71, 43.49)
Shannon
Continuous [mean (SD)]	[5.25 (0.80)]	[4.96 (0.78)]	1.70 (0.65, 5.36)	0.30	2.06 (0.68, 8.24)	0.24
Quantile 1 (3.19–5.06)	3 (27.3)	11 (50.0)	1.00 (referent)	0.22	1.00 (referent)	0.12
Quantile 2 (5.06–6.22)	8 (72.7)	11 (50.0)	2.70 (0.59, 14.74)		4.38 (0.76, 35.56)
PD whole tree
Continuous [mean (SD)]	[21.36 (3.04)]	20.12 (3.28)	1.10 (0.90, 1.48)	0.29	1.16 (0.90, 1.58)	0.27
Quantile 1 (14.06–19.37)	1 (9.1)	11 (50.0)	1.00 (referent)	0.04	1.00 (referent)	0.03
Quantile 2 (19.38–26.75)	10 (90.9)	11 (50.0)	10.00 (1.52, 199.93)		26.72 (2.34, 1,084)

^aAlpha diversity measures were dichotomized based on median value among the matched cancer-free controls
^bCovariates for logistic regression models included: age(continuous), race (black vs. white), and BMI (continuous)
CI, confidence interval; OR, odds ratio; PD, phylogenetic diversity

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