Table 3 Associations of phylum and genus level relative abundances with colorectal cancer among Black and White women (N = 33; 11 colorectal cancer cases, and 22 cancer-free controls)
Colorectal cancer | Cancer-free | Unadjusted | Adjusted | |||
|---|---|---|---|---|---|---|
Mean % relative abundance (SD) | Mean % relative abundance (SD) | OR (95% CI) | P-value | OR (95% CI)b | P-value | |
11 | 22 | |||||
Phylum | ||||||
Firmicutes | 66.91 (16.90) | 58.80 (14.33) | 9.30 (0.47, 353.87) | 0.18 | 10.52 (0.52, 417.32) | 0.15 |
Bacteroidetes | 22.97 (14.39) | 27.70 (16.59) | 0.88 (0.53, 1.49) | 0.61 | 0.88 (0.49, 1.56) | 0.64 |
Proteobacteria | 4.19 (5.81) | 3.76 (6.04) | 0.88 (0.53, 1.45) | 0.61 | 0.90 (0.52, 1.52) | 0.68 |
Verrucomicrobia | 2.34 (3.27) | 4.32 (9.17) | 0.97 (0.72, 1.31) | 0.84 | 0.98 (0.71, 1.36) | 0.88 |
Actinobacteria | 2.67 (3.33) | 3.90 (5.76) | 0.94 (0.51, 1.68) | 0.82 | 0.96 (0.53, 1.75) | 0.90 |
Archaea; Euryarchaeota | 0.21 (0.34) | 0.43 (1.22) | 1.10 (0.74, 1.51) | 0.78 | 1.08 (0.75, 1.60) | 0.66 |
Tenericutes | 0.03 (0.06) | 0.40 (1.29) | 0.61 (0.29, 1.02) | 0.10 | 0.56 (0.26, 0.95) | 0.06 |
Cyanobacteria | 0.01 (0.05) | 0.31 (0.77) | 0.88 (0.58, 1.28) | 0.53 | 0.91 (0.59, 1.36) | 0.65 |
Bacteria other | 0.08 (0.09) | 0.23 (0.63) | 1.20 (0.79, 1.96) | 0.39 | 1.34 (0.81, 2.33) | 0.27 |
Fusobacteria | 0.49 (1.05) | 0.00 (0.00) | 6.00 (1.93, 62.75) | 0.03 | 8.16 (2.24, 186.35) | 0.03 |
Phylum; class: order; family; genusa | ||||||
Bacteroides | 18.86 (13.33) | 19.70 (14.15) | 0.95 (0.59, 1.59) | 0.82 | 0.96 (0.57, 1.67) | 0.88 |
Blautia | 14.64 (12.12) | 14.04 (10.06) | 1.10 (0.42, 3.14) | 0.80 | 1.19 (0.40, 3.57) | 0.75 |
Coprococcus | 8.67 (12.47) | 4.98 (4.94) | 1.50 (0.71, 3.61) | 0.28 | 1.52 (0.66, 3.85) | 0.33 |
Ruminococcus | 6.62 (3.51) | 5.89 (4.79) | 1.40 (0.77, 3.18) | 0.33 | 1.41 (0.75, 3.34) | 0.34 |
Faecalibacterium | 6.59 (5.12) | 5.02 (5.07) | 1.30 (0.89, 2.29) | 0.25 | 1.32 (0.88, 2.38) | 0.26 |
[Ruminococcus] | 4.22 (4.06) | 4.88 (4.84) | 0.72 (0.28, 1.72) | 0.47 | 0.61 (0.21, 1.63) | 0.34 |
Akkermansia | 2.32 (3.26) | 4.31 (9.17) | 0.98 (0.73, 1.32) | 0.89 | 0.99 (0.72, 1.37) | 0.94 |
Roseburia | 3.90 (3.88) | 2.34 (2.22) | 1.80 (0.95, 4.30) | 0.13 | 1.83 (0.94, 4.66) | 0.13 |
Bifidobacterium | 1.68 (2.91) | 1.69 (3.04) | 1.00 (0.73, 1.45) | 0.90 | 1.06 (0.74, 1.53) | 0.76 |
Porphyromonas | 0.22 (0.62) | 0.00 (0.00) | 1.50 (0.85, 2.95) | 0.21 | 1.68 (0.92, 3.74) | 0.12 |
Prevotella | 0.01 (0.01) | 2.75 (8.26) | 0.73 (0.41, 1.03) | 0.15 | 0.74 (0.41, 1.06) | 0.18 |
Lactobacillus | 0.09 (0.21) | 0.05 (0.08) | 1.10 (0.49, 2.24) | 0.83 | 1.14 (0.48, 2.60) | 0.75 |
Pseudoramibacter_Eubacterium | 0.01 (0.02) | 0.11 (0.21) | 0.79 (0.48, 1.20) | 0.30 | 0.82 (0.49, 1.29) | 0.41 |
Clostridium | 0.17 (0.25) | 0.32 (0.43) | 0.77 (0.47, 1.20) | 0.25 | 0.76 (0.45, 1.23) | 0.27 |
Lachnospira | 0.45 (0.45) | 0.44 (0.68) | 1.10 (0.78, 1.73) | 0.56 | 1.11 (0.77, 1.74) | 0.60 |
Butyricicoccus | 0.00 (0.00) | 0.01 (0.02) | 0.74 (0.27, 1.85) | 0.52 | 0.67 (0.22, 1.81) | 0.44 |
Clostridium | 0.06 (0.08) | 0.04 (0.07) | 1.70 (1.01, 3.45) | 0.07 | 1.75 (1.00, 3.62) | 0.08 |
[Eubacterium] | 0.36 (0.53) | 0.20 (0.38) | 1.10 (0.70, 1.69) | 0.72 | 1.28 (0.76, 2.30) | 0.37 |
Fusobacterium | 0.49 (1.05) | 0.00 (0.00) | 6.00 (1.93, 62.75) | 0.03 | 8.16 (2.24, 186.35) | 0.03 |
Sutterella | 0.62 (0.51) | 0.83 (0.91) | 1.10 (0.80, 1.51) | 0.66 | 1.08 (0.78, 1.56) | 0.64 |
Succinivibrio | 0.00 (0.00) | 0.04 (0.17) | 1.00 (0.38, 2.25) | 1.00 | 1.03 (0.40, 2.38) | 0.94 |
Methanobrevibacter | 0.20 (0.33) | 0.42 (1.19) | 1.10 (0.74, 1.52) | 0.78 | 1.08 (0.75, 1.60) | 0.67 |
Gemellaceae (family) | 0.02 (0.02) | 0.01 (0.02) | 2.00 (0.99, 4.95) | 0.08 | 2.32 (1.07, 6.20) | 0.05 |
Peptostreptococcus | 0.22 (0.54) | 0.00 (0.00) | 1.80 (1.02, 4.11) | 0.08 | 2.16 (1.14, 5.12) | 0.04 |
Dialister | 0.31 (0.35) | 0.34 (0.58) | 1.10 (0.78, 1.46) | 0.70 | 1.09 (0.78, 1.57) | 0.62 |
Parvimonas | 0.03 (0.05) | 0.01 (0.04) | 1.00 (0.43, 2.47) | 0.92 | 1.10 (0.42, 2.88) | 0.84 |