Table 1 Adhesins of extraintestinal pathogenic E. coli
From: Adhesive threads of extraintestinal pathogenic Escherichia coli
Adhesin | Gene | Receptor specificity | Cell adherence: in vitro and in vivo infection models | Reference |
|---|---|---|---|---|
Type 1 fimbriae | fim | Mannose oligosaccharides (Mono- and Tri-mannose) | Human bladder epithelium, Chicken tracheal and gut explants, colonic and ileal enterocytes | |
P fimbriae | pap | P-blood group antigen-specific glycosphingolipids (α-D-Galp-(1-4)-β-D-Galp) | Human kidney, colonic and ileal enterocytes | |
Curli | csg | Matrix and Plasma Proteins (Fibronectin, Laminin, Plasminogen, H-Kininogen) | Chicken tracheal and gut explants | |
S fimbriae | sfa | Neuraminic acid (Sialyl galactosides) | Human bladder and kidney epithelium, Brain endothelium, colonic and ileal enterocytes | |
F1C fimbriae | foc | Lactosylceramide containing glycolipids | Buccal epithelium, Collecting ducts and distal tubules of human kidney, renal tubulus cells | |
Dr fimbriae | dra | Dr blood group antigen, Decay accelerating factor (DAF) | Basement membranes of human and canine kidneys, Bowman's capsule, Bladder epithelium, colonic and ileal enterocytes | |
Afimbrial adhesins | afa | DAF | Uroepithelial cells | |
Temperature sensitive haemagglutinin | tsh | Haemoglobin, Fibronectin, Collagen IV | Chicken erythrocytes | |
UPEC trimeric autotransporter adhesin | upa | Fibronectin, Laminin | Human bladder epithelial cells | [93] |
ExPEC Adhesin I | yqi | n.d. | Chicken lung epithelium, Chicken fibroblasts, Canine kidney epithelial cells | [96] |