Skip to main content

Table 4 The study results on Monensin

From: Monensin causes dose dependent inhibition of Mycobacterium avium subspecies paratuberculosis in radiometric culture

Monensin         
%–ΔcGI         
Monensin MAP M. avium   M. bovis
μg/ml Human    Bovine   Bovine   BCG
  Dominic UCF-4 Ben 19698 303 25291 101 19015
1 -52% -73% -21% -14% -21% -25% 7% -44%
4 -77% -93% -51% -45% -73% -54% 3% -69%
16 -93% -96% -93% -62% -94% -69% 4% -92%
64 -94% -97% -97% -65% -97% -87% 8% -98%
  1. Data are presented for the agent evaluated in this study, the "Growth Enhancer" Monensin. Data are given for a representative experiment of each mycobacterial strain studied. Note the dose dependent inhibition in every mycobacterial strain except M. avium subspecies avium 101. The dose dependent inhibition was observed in each of the 21 experiments where MAP was the strain studied (replicative data not presented.) %–ΔcGI = Percent decrease in cumulative Growth Index compared to solvent control (see Methods.)