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Figure 1 | Gut Pathogens

Figure 1

From: Helicobacter pylori infection induced gastric cancer; advance in gastric stem cell research and the remaining challenges

Figure 1

Helicobacter pylori infection, stem cells and gastric cancer. H. pylori infection induces chronic inflammation within local gastric mucosa; the proinflammatory microenvironment may disrupt stem/progenitor cell proliferation and differentiation. H. pylori- or inflammation-induced molecular damages in these cells could be carried to the descendants and facilitate tumor initiation. In addition, H. pylori CagA-, cag PAI-positive strains induce multiple oncogenic signaling and epigenetic alteration in epithelial cells. Persistent activation of these oncogenic pathways, alterations of epigenetic profile and deregulation of stem cell differentiation provide important molecular mechanisms toward H. pylori- or inflammation-induced carcinogenesis. (Image is for illustration purpose, does not scale to real size or proportion of cells, and is made by Microsoft PowerPoint software; CagA: Cytotoxin-associated antigen A; PGN: Peptidoglycan)

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Gut Pathogens

ISSN: 1757-4749