Figure 2

Statistical comparisons of three dominant gut bacteria genera between tumor and normal tissues. A-C respectively showed two different variation patterns of each of three dominant bacteria genera (Roseburia, Microbacterium, and Anoxybacillus)–either the overrepresentation in tumor sites or in normal sites (separated by slash). Those tumor/normal tissue pairs with significant differentiation of dominant bacteria abundance were marked by a box. D, significantly increasing Roseburia in tumor tissue (mean, t-test) corresponding to four tumor/normal pairs from 50% of patients marked by a box (A); E, significant decreasing Microbacterium in tumor (median, Mann-Whitney rank sum test) corresponding to six tumor/normal pairs from 75% of patients marked by box (B); F, significant decreasing Anoxybacillus in tumor (median, Mann-Whitney rank sum test) corresponding to six tumor/normal pairs from 75% of patients marked by a box (C). Sample names started with their corresponding studied patient number - S00X (X= 1, 2, 4, 5, 6, 7, 8, and 9) and the following tissue type (C stands for cancer tissue and H for matched adjacent health tissue).