Oral administration of L. lactis NCDO 2118 improved colon shortening and macroscopic score of colitis . (A) Experimental protocol. C57BL/6 mice received 2% DSS for 7 days. L. lactis NCDO 2118 was continually administered for 4 consecutive days during the remission period of colitis (arrows) between the first and second course of colitis. The control group received medium. Mice were sacrificed at days 14 and 21 (arrowheads). (B) Body weight from day 0 to day 21. (C) Colon length measured in cm. (D) Macroscopic score of colitis, including scores related to body weight, diarrhea and rectal bleeding. Bars are the mean of 6 mice/group, and the data are representative of three independent experiments; ANOVA, Tukey post-test. *, p < 0.05, **, p < 0.01, ***, p < 0.001.