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Table 2 Table summarising the histopathological alterations and colonisation density observed in the canine stomach, according to the positive NHPH species-specific PCR results, positive genus results and negative results

From: Presence and significance of Helicobacter spp. in the gastric mucosa of Portuguese dogs

  PCR positive results with specific species identification, regardless gastric location (percent&number) (n = 33) Positive results for Helicobacter spp. (percent&number) (n = 27) Negative results (percent & number) (n = 9) p
  Hh Hf Hb Hs Hf + Hb Hh + Hs Hh + Hf Hb + Hs Hf + Hb + Hs
Histopathology grading             
(Day et al., 2008)             
Normal 3.0 (1/33) 0 0 3.0 (1/33) 0 0 0 0 0 7.4 (2/27) 11.1 (1/9) NS
 Mild gastritis 15.2 (5/33) 3.0 (1/33) 3.0 (1/33) 6.1 (2/33) 0 18.2 (6/33) 3.0 (1/33) 3.0 (1/33) 6.1 (2/33) 44.4 (12/27) 33.3 (3/9)
 Moderate gastritis 12.1 (4/33) 3.0 (1/33) 3.0 (1/33) 0 3.0 (1/33) 9.1 (3/33) 0 0 0 48.1 (13/27) 44.4 (4/9)
 Marked gastritis 0 0 0 0 0 6.1 (2/33) 0 0 0 0 11.1 (1/9)
Epithelial injury             
 Mild 27.3 (9/33) 3.0 (1/33) 0 9.1 (3/33) 3.0 (1/33) 30.3 (10/33) 0 3.0 1/3(3) 6.1 (2/33) 77.8 (21/27) 33.3 (3/9) 0.003
 Moderate 3.0 (1/33) 3.0 (1/33) 6.1 (2/33) 0 0 0 3.0 (1/33) 0 0 14.8 (4/27) 11.1 (1/9)
Fibrosis/mucosal atrophy             
 Mild 18.2 (6/33) 6.1 (2/33) 6.1 (2/33) 6.1 (2/33) 0 18.2 (6/33) 0 0 3.0 (1/33) 55.6 (15/27) 33.3 (3/9) NS
 Moderate 3.0 (1/33) 0 0 0 3.0 (1/33) 0 0 0 0 3.7 (1/27) 11.1 (1/9)
Intraepithelial lymphocytes             
 Mild 15.2 (5/33) 3.0 (1/33) 6.1 (2/33) 6.1 (2/33) 0 15.2 (5/33) 0 0 6.1 (2/33) 29.6 (8/27) 11.1 (1/9) 0.016
 Moderate 3.0 (1/33) 3.0 (1/33) 0 0 3.0 (1/33) 9.1 (3/33) 0 0 0 14.8 (4/27) 0
Lymphofollicular hyperplasia             
 Mild 6.1 (2/33) 0 0 0 3.0 (1/33) 0 0 0 0 29.6 (8/27) 11.1 (1/9) NS
Bacterial density (based on the IHC results)            NA  
+ 0 0 0 0 0 0 0 0 0 14.8 (4/27)   
++ 3.0 (1/33) 0 0 0 3.0 (1/33) 0 0 0 0 25.9 (7/27)   
+++ 24.2 (8/33) 6.1 (2/33) 6.1 (2/33) 9.1 (3/33) 0 33.3 (11/33) 3.0 (1/33) 3.0 (1/33) 6.1 (2/33) 51.9 (14/27)   
  1. Legend: Hh, H. heilmannii-like; Hf, H.felis; Hb, H. bizzozeronnii; Hs, H. salomonis. Bacterial density: +, few organisms; ++, moderate number of organisms; +++, large number of organisms. NA, not applicable. NS, not significant (p > 0.05).