Table 2 Summary of protein coding sequences annotated as belonging to the “Virulence, Disease, and Defense” subsystem in the SEED database
Subsystem | Role | Location |
|---|---|---|
Streptococcus pyogenes recombinatorial zone | Chaperonin (heat shock protein 33) | Contig 3 |
Colicin V and bacteriocin production cluster | Dihydrofolate synthase | Contig 3 |
Folylpolyglutamate synthase | Contig 3 | |
Amidophosphoribosyltransferase | Contig 3 | |
Acetyl-coenzyme A carboxyl transferase beta chain | Contig 3 | |
Colicin V production protein | Contig 3 | |
tRNA pseudouridine synthase A | Contig 3 | |
Copper homeostasis | Negative transcriptional regulator-copper transport operon | Contig 3 |
Copper-translocating P-type ATPase | Contig 3 | |
Copper chaperone | Contig 3 | |
Cobalt-zinc-cadmium resistance | DNA-binding heavy metal response regulator | Contig 3 |
Cobalt-zinc-cadmium resistance protein | Contig 3 | |
Transcriptional regulator, MerR family | Contig 3 | |
Resistance to fluoroquinolones | DNA gyrase subunit B | Contig 3 |
DNA gyrase subunit A | Contig 3 | |
Topoisomerase IV subunit B | Contig 3 | |
Topoisomerase IV subunit A | Contig 3 | |
Copper homeostasis: copper tolerance | Cytoplasmic copper homeostasis protein CutC | Contig 3 |
Magnesium and cobalt efflux protein CorC | Contig 3 | |
Beta-lactamase | Beta-lactamase class C and other penicillin-binding proteins | Contig 3 |
Beta-lactamase | Contig 3 | |
Metal-dependent hydrolases of the beta-lactamase superfamily I | Contig 3 | |
Cadmium resistance | Cadmium resistance protein | Contig 1 |
Cadmium efflux system accessory protein | Contig 1 | |
Multidrug resistance efflux pumps | Multidrug resistance efflux pump PmrA | Contig 3 |
Multi antimicrobial extrusion protein [Na(+)/drug antiporter], MATE family of MDR efflux pumps | Contig 3 | |
Multidrug and toxin extrusion (MATE) family efflux pump YdhE/NorM, homolog | Contig 3 | |
Multidrug-efflux transporter, major facilitator superfamily (MFS) | Contig 3 |