Fig. 3

Histologic analysis of the colon in C. albicans and DSS-induced colitis. a, c correspond to colon sections from wild-type mice receiving water as controls (CTL), and C. albicans (Ca) respectively. e, g, i, and k correspond to colon sections from wild-type C. albicans and DSS (CaD), TLR1^−/− CaD, TLR2^−/− CaD, and TLR6^−/− CaD mice, respectively. In the absence of DSS, no significant differences in the colon sections were observed between control animals (not inoculated) and those that received C. albicans (a, c). The colon sections from wild-type CaD and TLR6^−/− CaD mice show an inflammatory cell infiltrate in colonic wall structures (b, h). The colon sections from TLR1^−/− CaD and TLR2^−/− CaD mice display a high inflammatory cell infiltrate in colonic wall structures and massive tissue destruction (asterisk, h, j). The scale bars represent 50 µm (a, c, e, g, i, k) and 10 µm (b, d, f, h, j l)